安非他酮和 SSRI 类抗抑郁药对青少年睡眠时腿部运动活动和颏肌张力的影响。
Effects of bupropion and SSRI antidepressants on leg movement activity and chin muscle tone during sleep in adolescents.
机构信息
Seattle Children's Hospital and University of Washington, Seattle, Washington.
Institute of Molecular Bioimaging and Physiology, National Research Council, Milan, Italy.
出版信息
J Clin Sleep Med. 2023 Jan 1;19(1):151-161. doi: 10.5664/jcsm.10282.
STUDY OBJECTIVES
To evaluate the effects of bupropion on periodic limb movements during sleep (PLMS) and chin electromyography tone in children taking it for their mood disorder, compared to the effects of selective serotonin reuptake inhibitors (SSRIs) and of bupropion combined with SSRIs.
METHODS
Six adolescents (aged 16.0 ± 0.63 years) taking bupropion alone and 6 adolescents (aged 15.9 ± 1.36 years) taking bupropion in combination with an SSRI antidepressant were recruited, along with 10 adolescents (aged 16.2 ± 0.2 years) taking different SSRIs, and they were also enrolled together with 17 age- and sex-matched control patients (aged 15.5 ± 1.26 years). Polysomnographic studies were obtained, and participants' leg movement activity during sleep and muscle tone were assessed quantitatively (atonia index) during all sleep stages.
RESULTS
Participants taking SSRIs showed PLMS indices significantly higher than those of control patients, whereas adolescents taking bupropion showed only slightly increased indexes of nonperiodic leg movements during sleep. No differences in PLMS were observed between adolescents taking bupropion alone or in association with SSRIs. The atonia index showed, within each sleep stage, the lowest values in the 2 groups taking SSRIs and the highest in the control patients; adolescents taking bupropion alone tended to show values slightly smaller than those of the control patients.
CONCLUSIONS
We found that similar to adults, in adolescents SSRIs but not bupropion are associated with increased PLMS. Bupropion also seems to counteract the SSRI-induced increase of PLMS, when administered in combination; thus, the dopaminergic effect of bupropion seems to outmatch the antidopaminergic action of SSRIs. Conversely, bupropion does not counteract the effects of SSRIs on chin electromyography tone.
CITATION
DelRosso LM, Mogavero MP, Fickensher A, Bruni O, Schenck CH, Ferri R. Effects of bupropion and SSRI antidepressants on leg movement activity and chin muscle tone during sleep in adolescents. 2023;19(1):151-161.
研究目的
评估安非他酮对接受其治疗情绪障碍的儿童睡眠周期性肢体运动（PLMS）和颏肌肌电图张力的影响，并与选择性 5-羟色胺再摄取抑制剂（SSRIs）和安非他酮联合 SSRIs 的影响进行比较。
方法
招募了 6 名（年龄 16.0 ± 0.63 岁）单独服用安非他酮的青少年和 6 名（年龄 15.9 ± 1.36 岁）服用安非他酮联合 SSRIs 抗抑郁药的青少年，同时还招募了 10 名（年龄 16.2 ± 0.2 岁）服用不同 SSRIs 的青少年，以及 17 名年龄和性别匹配的对照患者（年龄 15.5 ± 1.26 岁）。获得多导睡眠图研究，评估参与者在所有睡眠阶段的腿部运动活动和肌肉张力（弛缓指数）的定量变化。
结果
服用 SSRIs 的参与者的 PLMS 指数明显高于对照组，而服用安非他酮的青少年在睡眠期间仅显示出非周期性腿部运动指数略有增加。单独服用安非他酮或与 SSRIs 联合服用的青少年之间，PLMS 无差异。在每个睡眠阶段内，弛缓指数显示，服用 SSRIs 的两组最低，对照组最高；单独服用安非他酮的青少年的数值略小于对照组。
结论
我们发现，与成人相似，SSRIs 而不是安非他酮与青少年的 PLMS 增加有关。当安非他酮联合 SSRIs 给药时，它似乎也能对抗 SSRIs 引起的 PLMS 增加，因此，安非他酮的多巴胺能作用似乎超过了 SSRIs 的抗多巴胺能作用。相反，安非他酮不能对抗 SSRIs 对颏肌肌电图张力的影响。
引用
DelRosso LM、Mogavero MP、Fickensher A、Bruni O、Schenck CH、Ferri R. 安非他酮和 SSRIs 抗抑郁药对青少年睡眠时腿部运动活动和颏肌肌电张力的影响。睡眠医学。2023；19(1):151-161.
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