不宁腿综合征和睡眠周期性肢体运动的长期精神和心血管发病率和死亡率。

The Long-Term Psychiatric and Cardiovascular Morbidity and Mortality of Restless Legs Syndrome and Periodic Limb Movements of Sleep.

机构信息

Sleep Disorders Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, One Bowdoin Square, 10th Floor, Boston, MA 02114, USA.

Sleep Disorders Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, One Bowdoin Square, 10th Floor, Boston, MA 02114, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.

出版信息

Sleep Med Clin. 2021 Jun;16(2):279-288. doi: 10.1016/j.jsmc.2021.02.005. Epub 2021 Apr 15.

DOI:10.1016/j.jsmc.2021.02.005

PMID:33985653

Abstract

Restless legs syndrome (RLS) is a sensory-motor neurological disorder that is associated with high levels of distress and sleep disturbance. Cross-sectional and longitudinal evidence suggests that individuals suffering from RLS may be at an increased risk of certain psychiatric illnesses and cardiovascular diseases. There also is evidence for increased mortality rates in RLS patients, although contrasting results do exist. Periodic limb movements of sleep (PLMS), repetitive leg movement observed in most RLS patients, and sleep disturbance may mediate the relationship between RLS and long-term morbidity. This article summarizes the literature investigating the potential consequences of both RLS and PLMS.

摘要

不宁腿综合征（RLS）是一种感觉运动神经系统疾病，与高度痛苦和睡眠障碍有关。横断面和纵向证据表明，患有 RLS 的个体可能面临某些精神疾病和心血管疾病的风险增加。RLS 患者的死亡率也有增加的证据，尽管存在相互矛盾的结果。睡眠周期性肢体运动（PLMS），即大多数 RLS 患者观察到的重复腿部运动，以及睡眠障碍可能在 RLS 和长期发病率之间的关系中起中介作用。本文总结了调查 RLS 和 PLMS 潜在后果的文献。