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多种方法,一种微生物:几种研究马拉色菌与模型宿主相互作用的方法。

Many ways, one microorganism: Several approaches to study Malassezia in interactions with model hosts.

机构信息

Grupo de Investigación Celular y Molecular de Microorganismos Patógenos (CeMoP), Departamento de Ciencias Biológicas, Universidad de los Andes, Bogotá, Colombia.

出版信息

PLoS Pathog. 2022 Sep 8;18(9):e1010784. doi: 10.1371/journal.ppat.1010784. eCollection 2022 Sep.

Abstract

Malassezia, a lipophilic and lipid-dependent yeast, is a microorganism of current interest to mycobiologists because of its role as a commensal or pathogen in health conditions such as dermatological diseases, fungemia, and, as discovered recently, cancer and certain neurological disorders. Various novel approaches in the study of Malassezia have led to increased knowledge of the cellular and molecular mechanisms of this yeast. However, additional efforts are needed for more comprehensive understanding of the behavior of Malassezia in interactions with the host. This article reviews advances useful in the experimental field for Malassezia.

摘要

马拉色菌是一种亲脂性和脂质依赖性酵母,由于其在皮肤病、真菌血症等健康状况下作为共生菌或病原体的作用,以及最近发现的在癌症和某些神经紊乱中的作用,引起了真菌学家的关注。马拉色菌研究中的各种新方法导致了对该酵母的细胞和分子机制的更多了解。然而,需要进一步努力以更全面地了解马拉色菌与宿主相互作用时的行为。本文综述了马拉色菌实验领域的研究进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59fc/9455852/6803986cfe87/ppat.1010784.g001.jpg

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