Immunology Research Center, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Biomaterials Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
Biomed Pharmacother. 2022 Sep;153:113483. doi: 10.1016/j.biopha.2022.113483. Epub 2022 Aug 9.
The tumor microenvironment (TME), as an immunosuppressive milieu, has a critical role in tumor progression and increases resistance to the conventional treatments. Among the abundant immunosuppressive cells in the TME, tumor-associated macrophages (TAMs) could be a promising target for reprogramming and potentiating the local anti-tumor response. On the other hand, hypoxia is a major barrier in treating solid tumors, which aggravates the situation and alleviates the anti-tumor immune responses. Moreover, catalase and catalase-mimicking compounds can efficiently participate in the TAMs polarization and hypoxia attenuation in the TME. In this review, we will introduce a practical and novel approach which can simultaneously reduce hypoxia and polarize TAMs in the TME. Furthermore, catalase therapeutic effects in combination with cancer therapy methods will be fully discussed. This work aims to inspire readers to explore new avenues for designing and development of next-generation catalase-based formulations for cancer therapy.
肿瘤微环境（TME）作为一种免疫抑制环境，在肿瘤进展中起着关键作用，并增加了对传统治疗的耐药性。在 TME 中丰富的免疫抑制细胞中，肿瘤相关巨噬细胞（TAMs）可能是重新编程和增强局部抗肿瘤反应的有希望的靶点。另一方面，缺氧是治疗实体瘤的主要障碍，它加剧了这种情况，并减轻了抗肿瘤免疫反应。此外，过氧化氢酶和类过氧化氢酶化合物可以有效地参与 TAMs 在 TME 中的极化和缺氧缓解。在这篇综述中，我们将介绍一种实用且新颖的方法，该方法可以同时降低 TME 中的缺氧程度并使 TAMs 极化。此外，还将充分讨论过氧化氢酶治疗与癌症治疗方法的联合应用。这项工作旨在启发读者探索设计和开发基于下一代过氧化氢酶的癌症治疗制剂的新途径。
