Zhou Hong, Luo Dan, Chen Dan, Tan Xi, Bai Xichen, Liu Zhi, Yang Xiangliang, Liu Wei
College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, People's Republic of China.
National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan, 430075, Hubei, People's Republic of China.
Clin Cosmet Investig Dermatol. 2021 Jul 13;14:867-887. doi: 10.2147/CCID.S313429. eCollection 2021.
Nanocarrier technology has been effectively applied to the development of drug delivery systems to overcome the limitations of traditional preparation. Its application has been extended to various pharmaceutical fields from injection preparation to oral preparation and external preparation, and now it has appeared in the field of cosmetics for beauty applications. The widespread influence of nanocarrier in the cosmetics industry is due to the fact that nanocarrier can effectively promote the percutaneous penetration and significantly increase skin retention of active components in functional cosmetics. Meanwhile, nanocarrier can effectively improve the water dispersion of insoluble active cosmetic ingredients, enhance the stability of efficacy components and achieve the codelivery of diverse cosmetics active ingredients. In this review, we summarized the current progress of nanocarrier technology in the functional cosmetics, including the types and the routes of dermal/transdermal drug delivery nanocarriers used in the functional cosmetics, the mechanism of nanocarriers promoting the percutaneous penetration of active cosmetic ingredients, the application and efficacy evaluation of different active cosmetic ingredients in nanocarriers and discussing the potential risks to human. This will provide a useful reference for the further development of nanocarriers in the field of functional cosmetics.
纳米载体技术已被有效地应用于药物递送系统的开发,以克服传统制剂的局限性。其应用已从注射制剂扩展到口服制剂和外用制剂等各种制药领域,现在已出现在用于美容应用的化妆品领域。纳米载体在化妆品行业的广泛影响归因于纳米载体能够有效促进功能性化妆品中活性成分的经皮渗透并显著增加其在皮肤中的保留量。同时,纳米载体可以有效改善不溶性活性化妆品成分的水分散性,增强功效成分的稳定性,并实现多种化妆品活性成分的共递送。在这篇综述中,我们总结了纳米载体技术在功能性化妆品中的当前进展,包括功能性化妆品中使用的皮肤/透皮给药纳米载体的类型和途径、纳米载体促进活性化妆品成分经皮渗透的机制、不同活性化妆品成分在纳米载体中的应用和功效评估,并讨论了对人体的潜在风险。这将为纳米载体在功能性化妆品领域的进一步发展提供有用的参考。