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细胞内途径和机制的彩色次生代谢物在癌症治疗。

Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy.

机构信息

Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 2-4, 200349 Craiova, Romania.

Department of Biochemistry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 2-4, 200349 Craiova, Romania.

出版信息

Int J Mol Sci. 2022 Sep 1;23(17):9943. doi: 10.3390/ijms23179943.

Abstract

Despite the great advancements made in cancer treatment, there are still many unsatisfied aspects, such as the wide palette of side effects and the drug resistance. There is an obvious increasing scientific attention towards nature and what it can offer the human race. Natural products can be used to treat many diseases, of which some plant products are currently used to treat cancer. Plants produce secondary metabolites for their signaling mechanisms and natural defense. A variety of plant-derived products have shown promising anticancer properties in vitro and in vivo. Rather than recreating the natural production environment, ongoing studies are currently setting various strategies to significantly manipulate the quantity of anticancer molecules in plants. This review focuses on the recently studied secondary metabolite agents that have shown promising anticancer activity, outlining their potential mechanisms of action and pathways.

摘要

尽管在癌症治疗方面取得了巨大的进展,但仍有许多不满意的方面,如广泛的副作用和耐药性。科学界对自然及其能为人类提供的东西的关注明显增加。天然产物可用于治疗许多疾病,其中一些植物产品目前用于治疗癌症。植物为其信号机制和天然防御产生次生代谢物。多种植物衍生产品在体外和体内均显示出有希望的抗癌特性。目前正在进行的研究不是在重新创造自然的生产环境,而是设定了各种策略来显著操纵植物中抗癌分子的数量。本综述重点介绍了最近研究的具有有希望的抗癌活性的次生代谢物药物,概述了它们的潜在作用机制和途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4de3/9456420/7099450a90a9/ijms-23-09943-g001.jpg

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