Drețcanu Georgiana, Știrbu Ioana, Leoplold Nicolae, Cruceriu Daniel, Danciu Corina, Stănilă Andreea, Fărcaș Anca, Borda Ileana Monica, Iuhas Cristian, Diaconeasa Zorița
Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 3-5 Calea Mănăştur, 400372 Cluj-Napoca, Romania.
Faculty of Physics, Babes-Bolyai University, Kogalniceanu 1, 400084 Cluj-Napoca, Romania.
Plants (Basel). 2022 Apr 20;11(9):1117. doi: 10.3390/plants11091117.
There has been a major shift in the collective mindset around the world in recent decades, both in terms of food and in terms of the treatment of chronic diseases. Increasing numbers of people are choosing to prevent rather than treat, which is why many consumers are choosing plant-based diets, mainly due to their bioactive compounds. A significant case of bioactive compound is flavonoids-a wide subclass of an even wider class of phytochemicals: polyphenols. Flavonoids are a broad topic of study for researchers due to their potential in the prevention and treatment of a broad range of cancers. The aim of this review is to inform/update the reader on the diversity, accessibility and importance of flavonoids as biomolecules that are essential for optimal health, focusing on the potential of these compounds in the prevention of various types of cancer. Along with conventional sources, this review presents some of the possible methods for obtaining significant amounts of flavonoids based on a slightly different approach, genetic manipulation.
近几十年来，全球范围内人们的集体观念发生了重大转变，在饮食和慢性病治疗方面均是如此。越来越多的人选择预防而非治疗，这就是许多消费者选择植物性饮食的原因，主要是因为其生物活性化合物。生物活性化合物的一个重要例子是黄酮类化合物——它是更广泛的一类植物化学物质：多酚类的一个宽泛子类。由于黄酮类化合物在预防和治疗多种癌症方面的潜力，它们是研究人员广泛研究的课题。本综述的目的是让读者了解/更新黄酮类化合物作为对最佳健康至关重要的生物分子的多样性、可获取性和重要性，重点关注这些化合物在预防各类癌症方面的潜力。除了传统来源，本综述还介绍了一些基于略有不同的方法——基因操作来获取大量黄酮类化合物的可能途径。
