Park Jae Hyun, Cho Hyun Seok, Yoon Jong Ho
Department of Surgery, Yonsei University Wonju College of Medicine, Wonju 26493, Korea.
Department of Radiology, Yonsei University Wonju College of Medicine, Wonju 26493, Korea.
Cancers (Basel). 2022 Aug 25;14(17):4106. doi: 10.3390/cancers14174106.
The rapidly increasing coincidence of thyroid cancer and metabolic syndrome (MS) in recent decades suggests an association between the two disorders. To investigate this association, we conducted a nationwide study of a large-scale patient cohort. Between 2009 and 2011, data were collected by the Korean National Health Insurance Service for 4,658,473 persons aged 40−70 years without thyroid cancer. During the six-year follow-up period, participants were monitored for the development of thyroid cancer. The relative risks and incidences of thyroid cancer were calculated using multivariate Cox proportional hazards regression analyses after adjusting for age and body mass index. The risk of thyroid cancer was significantly elevated in men and women with MS or MS components, except for hyperglycaemia (p = 0.723) or hypertriglyceridemia (p = 0.211) in men. The incidence of thyroid cancer per 10,000 person-years in individuals with MS was significantly higher in men (6.2, p < 0.001) and women (21.3, p < 0.001) compared to those without MS. Additionally, the risk of thyroid cancer increased significantly with an increasing number of MS components even in individuals with only one or two MS components. MS and its components were significantly associated with increased risk of developing thyroid cancer.
近几十年来，甲状腺癌与代谢综合征（MS）的并发率迅速上升，提示这两种疾病之间存在关联。为了研究这种关联，我们对一个大规模患者队列进行了一项全国性研究。2009年至2011年期间，韩国国民健康保险服务机构收集了4658473名年龄在40至70岁之间且无甲状腺癌的人的数据。在六年的随访期内，对参与者进行甲状腺癌发病监测。在调整年龄和体重指数后，使用多变量Cox比例风险回归分析计算甲状腺癌的相对风险和发病率。患有MS或MS组分的男性和女性患甲状腺癌的风险显著升高，但男性中的高血糖（p = 0.723）或高甘油三酯血症（p = 0.211）除外。与无MS的人相比，患有MS的男性（6.2，p < 0.001）和女性（21.3，p < 0.001）每10000人年的甲状腺癌发病率显著更高。此外，即使在只有一两种MS组分的个体中，甲状腺癌的风险也随着MS组分数量的增加而显著增加。MS及其组分与甲状腺癌发病风险增加显著相关。
