Burcher Kimberly M, Burcher Jack T, Inscore Logan, Bloomer Chance H, Furdui Cristina M, Porosnicu Mercedes
Wake Forest Baptist Medical Center, Winston-Salem, NC 27157, USA.
Lake Erie College of Medicine, Bradenton, FL 34211, USA.
Cancers (Basel). 2022 Aug 25;14(17):4116. doi: 10.3390/cancers14174116.
The role of the microbiome in the development and propagation of head and neck squamous cell cancer (HNSCC) is largely unknown and the surrounding knowledge lags behind what has been discovered related to the microbiome and other malignancies. In this review, the authors performed a structured analysis of the available literature from several databases. The authors discuss the merits and detriments of several studies discussing the microbiome of the structures of the aerodigestive system throughout the development of HNSCC, the role of the microbiome in the development of malignancies (generally and in HNSCC) and clinical applications of the microbiome in HNSCC. Further studies will be needed to adequately describe the relationship between HNSCC and the microbiome, and to push this relationship into a space where it is clinically relevant outside of a research environment.
微生物群落在头颈部鳞状细胞癌（HNSCC）发生和发展中的作用在很大程度上尚不清楚，相关知识滞后于已发现的微生物群与其他恶性肿瘤的关系。在本综述中，作者对来自多个数据库的现有文献进行了结构化分析。作者讨论了多项研究的优缺点，这些研究探讨了在HNSCC整个发展过程中，上呼吸道消化道系统结构的微生物群、微生物群在恶性肿瘤（一般情况和HNSCC中）发生中的作用以及微生物群在HNSCC中的临床应用。需要进一步的研究来充分描述HNSCC与微生物群之间的关系，并将这种关系拓展到在研究环境之外具有临床相关性的领域。
