急性常压低氧降低青年男性的执行功能，尽管 BDNF 浓度增加。
Acute Normobaric Hypoxia Lowers Executive Functions among Young Men despite Increase of BDNF Concentration.
机构信息
Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland.
Department of Sport, Institute of Physical Education, Kazimierz Wielki University, 85-064 Bydgoszcz, Poland.
出版信息
Int J Environ Res Public Health. 2022 Aug 30;19(17):10802. doi: 10.3390/ijerph191710802.
BACKGROUND
Decreased SpO during hypoxia can cause cognitive function impairment, and the effects of acute hypoxia on high-order brain functions such as executive processing remain unclear. This study's goal was to examine the impact of an acute normobaric hypoxia breathing session on executive function and biological markers.
METHODS
Thirty-two healthy subjects participated in a blind study performing two sessions of single 30 min breathing bouts under two conditions (normoxia (NOR) and normobaric hypoxia (NH), FIO = 0.135). The Stroop test was applied to assess cognitive function.
RESULTS
No significant difference was observed in the Stroop interference in the "reading" part of the test in either condition; however, there was a significant increase in the "naming" part under NH conditions ( = 0.003), which corresponded to a significant decrease in SpO ( < 0.001). There was a significant increase ( < 0.013) in the brain-derived neurotrophic factor (BDNF) level after NH conditions compared to the baseline, which was not seen in NOR. In addition, a significant drop ( < 0.001) in cortisol levels in the NOR group and a slight elevation in the NH group was noticed.
CONCLUSIONS
According to these findings, acute hypoxia delayed cognitive processing for motor execution and reduced the neural activity in motor executive and inhibitory processing. We also noted that this negative effect was associated with decreased SpO irrespective of a rise in BDNF.
背景
缺氧时 SpO 下降可导致认知功能障碍，急性缺氧对执行处理等高级脑功能的影响尚不清楚。本研究旨在探讨急性常压低氧呼吸对执行功能和生物标志物的影响。
方法
32 名健康受试者参与了一项盲法研究，在两种条件下（常氧（NOR）和常压低氧（NH），FIO=0.135）进行两次 30 分钟的单次呼吸。采用斯特鲁普测试评估认知功能。
结果
两种条件下测试的“阅读”部分的斯特鲁普干扰均无显著差异；然而，NH 条件下的“命名”部分显著增加（ = 0.003），这与 SpO 显著下降（<0.001）相对应。与基线相比，NH 条件后脑源性神经营养因子（BDNF）水平显著升高（<0.013），而 NOR 组未见升高。此外，NOR 组皮质醇水平显著下降（<0.001），NH 组略有升高。
结论
根据这些发现，急性低氧延迟了运动执行的认知处理，并降低了运动执行和抑制处理的神经活动。我们还注意到，这种负面影响与 SpO 下降有关，而与 BDNF 的升高无关。
Zotero 插件