Betesh-Abay Batya, Shiyovich Arthur, Davidian Shani, Gilutz Harel, Shalata Walid, Plakht Ygal
Department of Nursing, Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
Department of Cardiology, Rabin Medical Center, Petah Tikva, Israel and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 4941492, Israel.
J Clin Med. 2022 Aug 31;11(17):5145. doi: 10.3390/jcm11175145.
Fasting throughout the Muslim month of Ramadan may impact cardiovascular health. This study examines the association between the Ramadan period and acute myocardial infarction (AMI)-related outcomes among a Muslim population. The data were retrospectively extracted from a tertiary hospital (Beer-Sheva, Israel) database from 2002-2017, evaluating Muslim patients who endured AMI. The study periods for each year were: one month preceding Ramadan (reference period (RP)), the month of Ramadan, and two months thereafter (1840 days in total). A comparison of adjusted incidence rates between the study periods was performed using generalized linear models; one-month post-AMI mortality data were compared using a generalized estimating equation. Out of 5848 AMI hospitalizations, 877 of the patients were Muslims. No difference in AMI incidence between the Ramadan and RP was found ( = 0.893). However, in the one-month post-Ramadan period, AMI incidence demonstrably increased (AdjIRR = 3.068, = 0.018) compared to the RP. Additionally, the highest risk of mortality was observed among the patients that underwent AMI in the one-month post-Ramadan period (AdjOR = 1.977, = 0.004) compared to the RP. The subgroup analyses found Ramadan to differentially correlate with AMI mortality with respect to smoking, age, sex, diabetes mellitus, and hypertension, suggesting the Ramadan period is a risk factor for adverse AMI-related outcomes among select Muslim patients.
在整个穆斯林斋月期间禁食可能会影响心血管健康。本研究调查了斋月期间与穆斯林人群急性心肌梗死（AMI）相关结局之间的关联。数据是从一家三级医院（以色列贝尔谢巴）2002年至2017年的数据库中回顾性提取的，评估的是经历过AMI的穆斯林患者。每年的研究时间段为：斋月前一个月（参考期（RP））、斋月当月以及此后两个月（共1840天）。使用广义线性模型对各研究时间段之间的调整发病率进行比较；使用广义估计方程对AMI后一个月的死亡率数据进行比较。在5848例AMI住院病例中，有877例患者为穆斯林。未发现斋月期间和参考期之间的AMI发病率有差异（ = 0.893）。然而，与参考期相比，在斋月后的一个月内，AMI发病率明显增加（调整发病率比 = 3.068， = 0.018）。此外，与参考期相比，在斋月后一个月内发生AMI的患者中观察到最高的死亡风险（调整比值比 = 1.977， = 0.004）。亚组分析发现，斋月与AMI死亡率在吸烟、年龄、性别、糖尿病和高血压方面存在差异相关性，这表明斋月期间是部分穆斯林患者发生不良AMI相关结局的一个危险因素。
