College of Science, Yunnan Agricultural University, Kunming 650201, China.
Key Laborotory of Puer Tea Sciencs, Ministry of Education(YNAU), Yunnan Agricultural University, Kunming 650201, China.
Molecules. 2022 Aug 25;27(17):5427. doi: 10.3390/molecules27175427.
Tea contains high levels of the compound epigallocatechin gallate (EGCG). It is considered an important functional component in tea and has anti-cancer, antioxidant, and anti-inflammatory effects. The eight phenolic hydroxyl groups in EGCG's chemical structure are the basis for EGCG's multiple biological effects. At the same time, it also leads to poor chemical stability, rendering EGCG prone to oxidation and isomerization reactions that change its original structure and biological activity. Learning how to maintain the activity of EGCG has become an important goal in understanding the biological activity of EGCG and the research and development of tea-related products. Metal-organic frameworks (MOFs) are porous materials with a three-dimensional network structure that are composed of inorganic metals or metal clusters together with organic complexes. MOFs exploit the porous nature of the material itself. When a drug is an appropriate size, it can be wrapped into the pores by physical or chemical methods; this allows the drug to be released slowly, and MOFs can also reduce drug toxicity. In this study, we used MOF Zn(BTC) materials to load EGCG and investigated the sustained release effect of EGCG@MOF Zn(BTC) and the biological effects on wound healing in a diabetic mouse model.
茶含有高水平的化合物表没食子儿茶素没食子酸酯（EGCG）。它被认为是茶中一种重要的功能成分，具有抗癌、抗氧化和抗炎作用。EGCG 化学结构中的八个酚羟基是 EGCG 多种生物学效应的基础。同时，这也导致其化学稳定性差，使 EGCG 容易发生氧化和异构化反应，从而改变其原有结构和生物活性。了解如何保持 EGCG 的活性已成为理解 EGCG 的生物活性和茶相关产品研发的重要目标。金属-有机骨架（MOFs）是一种多孔材料，具有由无机金属或金属簇与有机配合物共同组成的三维网络结构。MOFs 利用了材料本身的多孔性质。当药物具有适当的尺寸时，可以通过物理或化学方法将其包裹到孔中；这使得药物能够缓慢释放，并且 MOFs 还可以降低药物毒性。在这项研究中，我们使用 MOF Zn（BTC）材料来负载 EGCG，并研究了 EGCG@MOF Zn（BTC）的持续释放效果及其在糖尿病小鼠模型中对伤口愈合的生物学影响。
