Department of Chemistry, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, Sumedang 45363, Indonesia.
Department of Chemistry Education, UIN Sunan Gunung Djati Bandung, Jl. A.H. Nasution No. 105, Bandung 40614, Indonesia.
Molecules. 2022 Aug 30;27(17):5586. doi: 10.3390/molecules27175586.
Hydroxyapatite (HA) is a well-known calcium phosphate ingredient comparable to human bone tissue. HA has exciting applications in many fields, especially biomedical applications, such as drug delivery, osteogenesis, and dental implants. Unfortunately, hydroxyapatite-based nanomaterials are synthesized by conventional methods using reagents that are not environmentally friendly and are expensive. Therefore, extensive efforts have been made to establish a simple, efficient, and green method to form nano-hydroxyapatite (NHA) biofunctional materials with significant biocompatibility, bioactivity, and mechanical strength. Several types of biowaste have proven to be a source of calcium in forming HA, including using chicken eggshells, fish bones, and beef bones. This systematic literature review discusses the possibility of replacing synthetic chemical reagents, synthetic pathways, and toxic capping agents with a green template to synthesize NHA. This review also shed insight on the simple green manufacture of NHA with controlled shape and size.
羟基磷灰石（HA）是一种众所周知的磷酸钙成分，类似于人体骨骼组织。HA 在许多领域都有令人兴奋的应用，特别是在生物医学应用中，如药物输送、成骨和牙种植体。不幸的是，基于羟基磷灰石的纳米材料是通过使用不环保且昂贵的试剂的传统方法合成的。因此，人们已经做出了广泛的努力来建立一种简单、高效和绿色的方法，以形成具有显著生物相容性、生物活性和机械强度的纳米羟基磷灰石（NHA）生物功能材料。已经证明几种类型的生物废物是形成 HA 的钙源，包括使用鸡蛋壳、鱼骨和牛骨。本系统文献综述讨论了用绿色模板代替合成化学试剂、合成途径和有毒封端剂来合成 NHA 的可能性。本综述还深入探讨了通过简单的绿色制造来控制 NHA 的形状和大小。
