NOTCH 信号通路与癌症中的非编码 RNA。

NOTCH signaling pathway and non-coding RNAs in cancer.

机构信息

Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai, 200444, China.

出版信息

Pathol Res Pract. 2019 Nov;215(11):152620. doi: 10.1016/j.prp.2019.152620. Epub 2019 Sep 3.

DOI:10.1016/j.prp.2019.152620

Abstract

Malignant tumors, known as cancer, seriously threaten human life and health. Cancer has the characteristics of abnormal cell differentiation, proliferation, invasion and metastasis. As a result, cancer often accompanied by poor prognosis and a lower survival rate. Notch signaling pathway is a highly conserved system in many multicellular organisms, and which has been proved to play a biological role in many cancers. In recent years, increasing evidence has shown that non-coding RNA can not only activate or inhibit NOTCH pathway, but also regulate the occurrence and development of cancer through NOTCH pathway. Therefore, we focus on the cancer-NOTCH-non-coding RNA axis in this review, and provide new ideas for cancer therapy.

摘要

恶性肿瘤，俗称癌症，严重威胁人类的生命和健康。癌症具有细胞分化异常、增殖、浸润和转移等特点。因此，癌症往往伴随着不良预后和较低的生存率。Notch 信号通路是在许多多细胞生物中高度保守的系统，已经证明它在许多癌症中具有生物学作用。近年来，越来越多的证据表明，非编码 RNA 不仅可以激活或抑制 NOTCH 通路，还可以通过 NOTCH 通路调节癌症的发生和发展。因此，我们在这篇综述中重点关注癌症-Notch-非编码 RNA 轴，并为癌症治疗提供新的思路。