Sullivan I D, Wren C, Bain H, Hunter S, Rees P G, Taylor J F, Bull C, Deanfield J E
Hospital for Sick Children, London.
Br Heart J. 1989 Feb;61(2):186-91. doi: 10.1136/hrt.61.2.186.
Balloon dilatation of the aortic valve was attempted in 34 consecutive children aged 16 months to 17 years (median 7 years), weight range 9-60 (median 22) kg. Previous surgical valvotomy had been performed in two patients (twice in one of them). The valve was not crossed in one patient. In the remaining 33 patients the pressure difference between the left ventricle and the ascending aorta during systole was reduced from 71 (30) to 28 (19) mm Hg. In 24 patients recatheterisation 2-19 (mean 9) months later showed gradients that were similar to those immediately after balloon dilatation (35 (20) v 31 (20) mm Hg). The two patients with the highest residual gradients immediately after balloon dilatation showed a spontaneous reduction in gradient at repeat catheterisation, whereas the patient who had twice had previous surgical valvotomy showed an increase in gradient from 37 to 99 mm Hg over nine months and required aortic root replacement. Balloon dilatation was repeated in two patients and this caused a further reduction in gradient. New aortic regurgitation occurred in nine (27%) patients (grade I, 8; grade II, 1) and aortic regurgitation was exacerbated (grade I to II) in two of the nine with pre-existing aortic regurgitation. External iliac artery avulsion occurred in one (3%) patient and two (6%) required intravenous streptokinase because the femoral artery became occluded. There were no other complications. Open valvotomy was performed in the child in whom the valve was not crossed, but no other child required aortic valve operation. Balloon dilatation of the aortic valve gave reasonable short term palliation and was well tolerated. It is an alternative to surgical valvotomy for initial palliation of congenital aortic stenosis in many children.
对34名年龄在16个月至17岁(中位数7岁)、体重9 - 60(中位数22)千克的连续儿童尝试进行主动脉瓣球囊扩张术。此前有两名患者接受过外科瓣膜切开术(其中一人接受过两次)。有一名患者瓣膜未被穿过。在其余33名患者中,收缩期左心室与升主动脉之间的压差从71(30)毫米汞柱降至28(19)毫米汞柱。24名患者在2 - 19(平均9)个月后再次导管检查显示梯度与球囊扩张后即刻相似(35(20)对31(20)毫米汞柱)。球囊扩张后即刻残余梯度最高的两名患者在重复导管检查时梯度自发降低,而此前接受过两次外科瓣膜切开术的患者在九个月内梯度从37毫米汞柱增加到99毫米汞柱,需要进行主动脉根部置换。两名患者重复进行球囊扩张,这导致梯度进一步降低。9名(27%)患者出现新的主动脉瓣反流(I级,8例;II级,1例),9例原有主动脉瓣反流的患者中有2例反流加重(从I级到II级)。一名(3%)患者发生髂外动脉撕裂,两名(6%)患者因股动脉闭塞需要静脉注射链激酶。无其他并发症。瓣膜未被穿过的儿童接受了开放瓣膜切开术,但没有其他儿童需要进行主动脉瓣手术。主动脉瓣球囊扩张术能提供合理的短期缓解,且耐受性良好。在许多儿童先天性主动脉狭窄的初始缓解治疗中,它是外科瓣膜切开术的一种替代方法。