Ahmad Syed Nawaz, Sameen Duri, Dar Mansoor Ahmad, Jallu Romaan, Shora Tajali Nazir, Dhingra Mansi
Department of Obstetrics and Gynecology, Government Medical College Anantnag, Anantnag, Jammu and Kashmir, India.
Department of Psychiatry, Government Medical College Anantnag, Anantnag, Jammu and Kashmir, India.
Int J Womens Health. 2022 Sep 2;14:1201-1210. doi: 10.2147/IJWH.S375739. eCollection 2022.
To determine the feto-maternal outcome in pregnant women infected with SARS-CoV-2 in comparison to non-infected pregnant women and plan management strategies.
A retrospective review of case records in the Department of Obstetrics and Gynecology for 1 year was conducted. A total of 6468 case files fulfilling the inclusion criteria were enrolled in the study. Patients who tested positive for SARS CoV-2 and fulfilled inclusion criteria were labeled as cases, whereas patients who tested negative were labeled as controls. Outcome measures including lower segment cesarean section (LSCS) rate, maternal and neonatal intensive care admission and feto-maternal mortality were compared between the two groups.
Our hospital was not an exclusive COVID-19 designated center, and 117 patients infected with SARS-CoV-2 fulfilling the inclusion criteria were enrolled in the study. Fever (67.52%), cough (56.41%), and altered smell (45.29%) were the frequently reported symptoms. Pneumonia affected 16.23% of the cases. LSCS rate was significantly higher in the COVID-19-infected patients (72.41%; OR 2.19; 95% CI 1.46-3.34; p<0.001). The rate of maternal ICU admission in COVID-19-infected pregnant women was 11.96% as compared to 0.8% in the non-infected women (OR 16.76; 95% CI 8.72-30.77; p<0.001). We observed a significantly higher maternal mortality in COVID-19-infected women (2.56%) [OR 41.61; 95% CI 7.65-203.5; p<0.001]. Viral RNA was detected in cord blood and nasopharyngeal swab of one neonate. The neonatal death ratio was high in infected mothers (2.6%) [OR 8.6; 95% CI 1.99-27.23; p<0.001].
Significant maternal morbidity, mortality, and neonatal mortality were observed in COVID-19-positive patients.
与未感染的孕妇相比，确定感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的孕妇的母婴结局，并制定管理策略。
对妇产科1年的病例记录进行回顾性研究。共有6468份符合纳入标准的病例档案纳入研究。SARS-CoV-2检测呈阳性且符合纳入标准的患者被标记为病例组，检测呈阴性的患者被标记为对照组。比较两组的结局指标，包括下段剖宫产（LSCS）率、孕产妇和新生儿重症监护病房收治情况以及母婴死亡率。
我院并非专门的COVID-19指定中心，117例感染SARS-CoV-2且符合纳入标准的患者纳入研究。发热（67.52%）、咳嗽（56.41%）和嗅觉改变（45.29%）是最常报告的症状。16.23%的病例出现肺炎。COVID-19感染患者的LSCS率显著更高（72.41%；比值比2.19；95%置信区间1.46 - 3.34；p<0.001）。COVID-19感染孕妇的孕产妇重症监护病房收治率为11.96%，未感染孕妇为0.8%（比值比16.76；95%置信区间8.72 - 30.77；p<0.001）。我们观察到COVID-19感染女性的孕产妇死亡率显著更高（2.56%）[比值比41.61；95%置信区间7.65 - 203.5；p<0.001]。在一名新生儿的脐带血和鼻咽拭子中检测到病毒RNA。感染母亲的新生儿死亡率较高（2.6%）[比值比8.6；95%置信区间1.99 - 27.23；p<0.001]。
在COVID-19阳性患者中观察到显著的孕产妇发病率、死亡率和新生儿死亡率。
