Xu Haitao, Jiang Caihong, Yao Fusheng, Liang Hong, Yan Hong, Chen Dangui, Wu Youzhi, Zhong Long
Department of Hematology, Anqing Municipal Hospital, Anqing Medical Center Affiliated to Anhui Medical University, Anqing, China.
Department of Pediatric Surgery, Anqing Municipal Hospital, Anqing Medical Center Affiliated to Anhui Medical University, Anqing, China.
J Oncol. 2022 Aug 30;2022:1445932. doi: 10.1155/2022/1445932. eCollection 2022.
Dysregulated epigenetic modifications play a critical role in cancer development where TRMT112 is a member of the transfer RNA (tRNA) methyltransferase family. Till now, no studies have revealed the linkage between TRMT112 expression and diverse types of tumors. Based on TCGA data, we first probed into the relation between TRMT112 and prognosis and the potential role of TRMT112 in tumor microenvironment across 33 types of tumor. TRMT112 presented with increased expression in most cancers, which was significantly prognostic. Furthermore, TRMT112 was associated with tumor-associated fibroblasts in a variety of cancers. Additionally, a positive relationship was identified between TRMT112 expression and multiple tumor-related immune infiltrations, such as dendritic cells, CD8+ T cells, macrophages, CD4+ T cells, neutrophils, and B cells in lung adenocarcinoma and breast invasive carcinoma. In summary, our results suggest that TRMT112 might be a potential prognostic predictor of cancers and involved in regulating multiple cancer-related immune responses to some extent.
失调的表观遗传修饰在癌症发展中起着关键作用，其中TRMT112是转移RNA（tRNA）甲基转移酶家族的成员。到目前为止，尚无研究揭示TRMT112表达与多种肿瘤类型之间的联系。基于TCGA数据，我们首先探究了TRMT112与预后之间的关系以及TRMT112在33种肿瘤类型中的肿瘤微环境中的潜在作用。TRMT112在大多数癌症中表达增加，具有显著的预后意义。此外，TRMT112与多种癌症中的肿瘤相关成纤维细胞有关。此外，在肺腺癌和乳腺浸润癌中，TRMT112表达与多种肿瘤相关免疫浸润（如树突状细胞、CD8 + T细胞、巨噬细胞、CD4 + T细胞、中性粒细胞和B细胞）之间存在正相关关系。总之，我们的结果表明，TRMT112可能是癌症的潜在预后预测指标，并在一定程度上参与调节多种癌症相关的免疫反应。
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