Lin Xiao-Qing, Zhang Mei-Xian, Chen Yan, Xue Ji-Ji, Chen He-Dan, Tung Tao-Hsin, Zhu Jian-Sheng
Department of Infectious Diseases, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, China.
Evidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, China.
Front Med (Lausanne). 2022 Aug 23;9:770933. doi: 10.3389/fmed.2022.770933. eCollection 2022.
This study aimed to explore COVID-19 vaccine hesitancy in Chinese adults and analyzed the relationship between knowledge, attitudes, practices (KAP), and COVID-19 vaccine hesitancy.
A population-based self-administered online survey was conducted in Taizhou, China to evaluate the population's hesitancy to receive COVID-19 vaccination. A total of 2.463 adults received the invitation for the survey through WeChat (A Chinese app that is used for chat, social media, and mobile payment), and 1.788 interviewees answered the structured questionnaire. The overall response rate was 72.6%.
Total 45.2% of people were hesitant about the COVID-19 vaccination. Using binary logistic regression analysis, we found low perception of safety (Model 3: Odds ratio = 2.977, Confidence interval: 2.237-3.963) and efficacy (Model 3: OR = 1.904, 95%CI: 1.462-2.479) of the COVID-19 vaccine in adults is the most important risk factor for COVID-19 vaccine hesitation. People who know more about COVID-19 vaccination are less hesitant (Model 2: OR = 0.967, 95% CI: 0.951-0.983). People who did not seek information independently about the COVID-19 vaccine are more likely to be skeptical (Model 4: OR = 1.300, 95% CI: 1.058-1.598, = 0.013).
In China, the population had higher levels of COVID-19 vaccine hesitation, and their knowledge of the COVID-19 vaccine, perceptions of safety and efficacy, and physical health status were significantly associated with vaccine hesitation. These results provide ideas for promoting COVID-19 vaccination and intervention and have far-reaching implications for further strengthening research on vaccine hesitancy in COVID-19 and exploring strategies for COVID-19 vaccine promotion.
本研究旨在探讨中国成年人对新冠疫苗的犹豫态度，并分析知识、态度、行为（KAP）与新冠疫苗犹豫之间的关系。
在中国泰州进行了一项基于人群的自填式在线调查，以评估人群对接种新冠疫苗的犹豫程度。共有2463名成年人通过微信（一款用于聊天、社交媒体和移动支付的中国应用程序）收到调查邀请，1788名受访者回答了结构化问卷。总体回复率为72.6%。
共有45.2%的人对新冠疫苗接种持犹豫态度。通过二元逻辑回归分析，我们发现成年人对新冠疫苗安全性（模型3：比值比=2.977，置信区间：2.237-3.963）和有效性（模型3：OR=1.904，95%CI：1.462-2.479）的认知度低是新冠疫苗犹豫的最重要风险因素。对新冠疫苗了解更多的人犹豫程度较低（模型2：OR=0.967，95%CI：0.951-0.983）。未自主寻求新冠疫苗信息的人更有可能持怀疑态度（模型4：OR=1.300，95%CI：1.058-1.598，P=0.013）。
在中国，人群对新冠疫苗的犹豫程度较高，他们对新冠疫苗的了解、对安全性和有效性的认知以及身体健康状况与疫苗犹豫显著相关。这些结果为促进新冠疫苗接种和干预提供了思路，对进一步加强新冠疫苗犹豫研究及探索新冠疫苗推广策略具有深远意义。
