Luyten F P, Verbruggen G, Veys E M
Clin Exp Rheumatol. 1987 Apr-Jun;5(2):103-10.
Some evidence is presented that the metabolism of visually intact cartilage taken from a knee with focal osteoarthritic lesions, may already be affected. Proteoglycan metabolism of articular cartilage from the macroscopically unaffected right knee and the osteoarthritic left knee of the same donor was assayed in long-term tissue culture. A good reparative response was found in the right knee with an increase in the relative amount of radiolabelled proteoglycan and proteoglycan aggregates, and in the total amount of labelled proteoglycan per mg dry tissue. No significant differences were found when the anteromedial, anterolateral and posterolateral areas were compared. Visually intact samples taken from the left knee, with a deep osteoarthritic cartilage erosion on the medial condyle, showed no accumulation of radiolabel into proteoglycan and proteoglycan aggregates for the enzymatically pretreated samples. This was interpreted as a repair failure.
有证据表明，取自患有局灶性骨关节炎病变膝关节的外观完好的软骨代谢可能已经受到影响。在长期组织培养中，对来自同一供体宏观上未受影响的右膝和骨关节炎左膝的关节软骨蛋白聚糖代谢进行了测定。右膝出现了良好的修复反应，放射性标记的蛋白聚糖和蛋白聚糖聚集体的相对量增加，每毫克干组织中标记蛋白聚糖的总量也增加。比较前内侧、前外侧和后外侧区域时未发现显著差异。取自左膝、内侧髁有深层骨关节炎软骨侵蚀的外观完好样本，对于经酶预处理的样本，未显示放射性标记积累到蛋白聚糖和蛋白聚糖聚集体中。这被解释为修复失败。
