Rosner I A, Goldberg V M, Getzy L, Moskowitz R W
Arthritis Rheum. 1979 Jan;22(1):52-8. doi: 10.1002/art.1780220108.
Estradiol valerate did not ameliorate experimentally induced osteoarthritis in the rabbit. Both normal and osteoarthritic cartilage were susceptible to estradiol suppression of proteoglycan synthesis. Protoeglycan concentration was not diminished with estradiol, suggesting estradiol suppression of proteoglycan catabolism. The severity of osteoarthritis was unchanged despite markedly decreased proteoglycan catabolism. The severity of osteoarthritis was unchanged despite markedly decreased protoeglycan synthesis in the estrogen treated animals. Osteophyte proteoglycan metabolism differed from other osteoarthritic lesions. Differences in the metabolism of femoral and tibial articular cartilage were observed.
戊酸雌二醇不能改善实验诱导的兔骨关节炎。正常和骨关节炎软骨均易受雌二醇对蛋白聚糖合成的抑制作用影响。雌二醇处理后蛋白聚糖浓度未降低，提示雌二醇抑制了蛋白聚糖分解代谢。尽管蛋白聚糖分解代谢明显降低，但骨关节炎的严重程度并未改变。在雌激素处理的动物中，尽管蛋白聚糖合成明显减少，但骨关节炎的严重程度并未改变。骨赘的蛋白聚糖代谢与其他骨关节炎病变不同。观察到股骨和胫骨关节软骨代谢存在差异。
