Wang Jun-Meng, Yang Ming-Xiao, Wu Qiao-Feng, Chen Ji, Deng Shu-Fang, Chen Lin, Wei Da-Neng, Liang Fan-Rong
Acupuncture and Moxibustion College, Chengdu University of Traditional Chinese Medicine, No.37, Road Shi-Er-Qiao, Jinniu District, Chengdu, 610075, Sichuan, China.
School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, SAR, China.
Chin Med. 2021 Jan 7;16(1):7. doi: 10.1186/s13020-020-00417-8.
Increasing evidence have indicated the relationship between intestinal dysbiosis and hypertension. We aimed to evaluate the effect of the electroacupuncture (EA) on intestinal microbiota in patients with stage 1 hypertension.
93 hypertensive patients and 15 healthy subjects were enrolled in this study. Applying a highly accurate oscillometric device to evaluate the antihypertensive effect of EA. 16S rRNA sequencing was used to profile stool microbial communities from Healthy group, Before treatment (BT) group and After treatment (AT) group, and various multivariate analysis approaches were used to assess diversity, composition and abundance of intestinal microbiota.
In this study, EA significantly decreased the blood pressure (BP) of hypertensive patients. Higher abundance of Firmicutes and lower Bacteroidetes abundance were observed in the BT group compared to the Healthy group. And EA treatment significantly decreased the Firmicutes/Bacteroidetes ratio compared to the BT group. Moreover, at the genus level, there was an increased abundance of Escherichia-Shigella in patients with hypertension, while Blautia were decreased, and EA reversed these changes.
Our study indicates that EA can effectively lower BP and improve the structure of intestinal microbiota which are correlate with the alteration of blood pressure by electroacupuncture.
Clinicaltrial.gov, NCT01701726. Registered 5 October 2012, https://clinicaltrials.gov/ct2/show/study/NCT01701726.
越来越多的证据表明肠道菌群失调与高血压之间存在关联。我们旨在评估电针（EA）对1期高血压患者肠道微生物群的影响。
本研究纳入了93例高血压患者和15名健康受试者。应用高精度示波装置评估电针的降压效果。采用16S rRNA测序对健康组、治疗前（BT）组和治疗后（AT）组的粪便微生物群落进行分析，并使用多种多变量分析方法评估肠道微生物群的多样性、组成和丰度。
在本研究中，电针显著降低了高血压患者的血压（BP）。与健康组相比，BT组中厚壁菌门丰度较高，拟杆菌门丰度较低。与BT组相比，电针治疗显著降低了厚壁菌门/拟杆菌门的比例。此外，在属水平上，高血压患者中埃希氏菌-志贺氏菌属丰度增加，而布劳特氏菌属丰度降低，电针逆转了这些变化。
我们的研究表明，电针可以有效降低血压，并改善肠道微生物群的结构，而这与电针引起的血压变化相关。
Clinicaltrial.gov，NCT01701726。于2012年10月5日注册，https://clinicaltrials.gov/ct2/show/study/NCT01701726。
