Sarangi Manoj Kumar, Padhi Sasmita, Patel L D, Rath Goutam, Nanda Sitansu Sekhar, Yi Dong Kee
Department of Pharmaceutics, School of Pharmaceutical Sciences, Sardar Bhagwan Singh University, Balawala, Dehradun, Uttarakhand, Pin-248001, India.
Department of Pharmaceutics, Parul Institute of Pharmacy, Parul University, Vadodara, Gujarat, Pin-391760, India.
J Drug Deliv Sci Technol. 2022 Oct;76:103764. doi: 10.1016/j.jddst.2022.103764. Epub 2022 Sep 6.
The world has witnessed an extreme vulnerability of a pandemic during 2020; originated from China. The coronavirus disease 2019 (COVID-19) is infecting and beginning deaths in thousands to millions, creating of the global economic crisis. Biosurfactants (BSs) can carry the prevention, control and management of pandemic out through diverse approaches, such as pharmaceutical, therapeutic, hygienic and environmental. The microbiotas having virulent intrinsic properties towards starting as easily as spreading of diseases (huge morbidity and mortality) could be inhibited via BSs. Such elements could be recognised for their antimicrobial activity, capability to interact with the immune system via micelles formation and in nanoparticulate synthesis. However, they can be used for developing novel and more effective therapeutics, pharmaceuticals, non-toxic formulations, vaccines, and effective cleaning agents. Such approaches can be utilized for product development and implemented for managing and combating the pandemic conditions. This review emphasized on the potentiality of BSs as key components with several ways for protecting against unknown and known pathogens, including COVID-19.
2020年,全球见证了一场源自中国的大流行病的极端脆弱性。2019冠状病毒病(COVID-19)正在感染数以千计乃至数百万的人并导致死亡,引发了全球经济危机。生物表面活性剂可以通过多种途径实现对大流行病的预防、控制和管理,例如制药、治疗、卫生和环境方面。对引发疾病(高发病率和死亡率)及疾病传播轻而易举的具有毒性内在特性的微生物群,可以通过生物表面活性剂加以抑制。这些物质因其抗菌活性、通过形成胶束与免疫系统相互作用的能力以及在纳米颗粒合成中的作用而得到认可。然而,它们可用于开发新型且更有效的治疗药物、药品、无毒制剂、疫苗和高效清洁剂。此类方法可用于产品开发,并用于管理和应对大流行状况。本综述着重阐述了生物表面活性剂作为关键成分在多种防范未知和已知病原体(包括COVID-19)方面的潜力。