Prevalence and Multi-Drug Resistance of Infection Among Presumptive Tuberculosis Adult Cases at Dilla University Referral Hospital, Dilla, Ethiopia.

INTRODUCTION

Streptococcus is the leading cause of community-acquired in Africa. The simultaneous occurrence of both infections leads to delayed diagnosis and inadequate treatment. The study aimed to determine the prevalence, antimicrobial susceptibility pattern and associated factors of infection among presumptive Tuberculosis adult cases at Dilla University Referral Hospital, Dilla, Ethiopia.

METHODS

An institution-based cross-sectional study was conducted on 422 presumptive TB cases visiting TB clinic at Dilla University Referral Hospital from April to June 2021. Following the Bartlett's criteria, the accepted sputum samples were cultured on Blood agar plate and chocolate agar plate. was identified and confirmed by typical colony morphology, alpha-hemolysis, gram staining, optochin susceptibility and bile solubility tests. Antimicrobial susceptibility test was done by using the Kirby-Bauer disc diffusion method. Semi-structured questionnaires were used to collect data. Bivariate and multivariate logistic regression analyses were done by using SPSS version 23.0, computer software.

RESULTS

The overall prevalence of in presumptive tuberculosis adult cases was 21.4% (95% CI: 17.7-25.5). . has a high level of resistance to penicillin (74.1%), tetracycline (78.7%) and Trimethoprim-sulfamethoxazole (46%). Multidrug resistance was observed in 46.1% of bacterial isolates. Being primary education, more than five family size and one or two rooms in the house had more likely to cause . infection.

CONCLUSION

This study revealed a relatively high prevalence of multidrug resistance of infection. Primary educational status, living in a crowded family, below two rooms in the house, had a significant association with infection.