Kaloro Halala Benyiam, Ali Musa Mohammed, Ormago Moges Desta
Referral Hospital, Dilla University, Dilla, Ethiopia.
School of Medical Laboratory Science, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.
Infect Drug Resist. 2022 Sep 5;15:5183-5191. doi: 10.2147/IDR.S375343. eCollection 2022.
Streptococcus is the leading cause of community-acquired in Africa. The simultaneous occurrence of both infections leads to delayed diagnosis and inadequate treatment. The study aimed to determine the prevalence, antimicrobial susceptibility pattern and associated factors of infection among presumptive Tuberculosis adult cases at Dilla University Referral Hospital, Dilla, Ethiopia.
An institution-based cross-sectional study was conducted on 422 presumptive TB cases visiting TB clinic at Dilla University Referral Hospital from April to June 2021. Following the Bartlett's criteria, the accepted sputum samples were cultured on Blood agar plate and chocolate agar plate. was identified and confirmed by typical colony morphology, alpha-hemolysis, gram staining, optochin susceptibility and bile solubility tests. Antimicrobial susceptibility test was done by using the Kirby-Bauer disc diffusion method. Semi-structured questionnaires were used to collect data. Bivariate and multivariate logistic regression analyses were done by using SPSS version 23.0, computer software.
The overall prevalence of in presumptive tuberculosis adult cases was 21.4% (95% CI: 17.7-25.5). . has a high level of resistance to penicillin (74.1%), tetracycline (78.7%) and Trimethoprim-sulfamethoxazole (46%). Multidrug resistance was observed in 46.1% of bacterial isolates. Being primary education, more than five family size and one or two rooms in the house had more likely to cause . infection.
This study revealed a relatively high prevalence of multidrug resistance of infection. Primary educational status, living in a crowded family, below two rooms in the house, had a significant association with infection.
在非洲，肺炎链球菌是社区获得性感染的主要病因。这两种感染同时发生会导致诊断延迟和治疗不充分。本研究旨在确定埃塞俄比亚迪拉市迪拉大学转诊医院疑似结核病成年病例中肺炎链球菌感染的患病率、抗菌药物敏感性模式及相关因素。
2021年4月至6月，在迪拉大学转诊医院结核病门诊对422例疑似结核病病例进行了一项基于机构的横断面研究。按照巴特利特标准，将合格的痰标本接种于血琼脂平板和巧克力琼脂平板上。通过典型菌落形态、α溶血、革兰氏染色、奥普托欣敏感性试验和胆汁溶解试验对肺炎链球菌进行鉴定和确认。采用 Kirby-Bauer 纸片扩散法进行抗菌药物敏感性试验。使用半结构化问卷收集数据。采用SPSS 23.0版计算机软件进行二元和多元逻辑回归分析。
疑似结核病成年病例中肺炎链球菌的总体患病率为21.4%（95%可信区间：17.7-25.5）。肺炎链球菌对青霉素（74.1%）、四环素（78.7%）和复方新诺明（46%）具有较高的耐药性。46.1%的细菌分离株观察到多重耐药。接受小学教育、家庭人口超过5人以及房屋有一两个房间更易引发肺炎链球菌感染。
本研究显示肺炎链球菌感染多重耐药的患病率相对较高。小学教育程度、生活在拥挤家庭以及房屋房间数不足两间与肺炎链球菌感染显著相关。
