Xue Shan-Shan, Pan Yingbo, Pan Wei, Liu Shujie, Li Na, Tang Bo
College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Centre of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University Jinan 250014 P. R. China
Chem Sci. 2022 Jul 27;13(33):9468-9484. doi: 10.1039/d2sc02587f. eCollection 2022 Aug 24.
Detecting the fluctuation and distribution of various bioactive species in biological systems is of great importance in determining diseases at their early stages. Metal complex-based probes have attracted considerable attention in bioimaging applications owing to their unique advantages, such as high luminescence, good photostability, large Stokes shifts, low toxicity, and good biocompatibility. In this review, we summarized the development of redox-active transition metal complex-based probes in recent five years with the metal ions of iron, manganese, and copper, which play essential roles in life and can avoid the introduction of exogenous metals into biological systems. The designing principles that afford these complexes with optical or magnetic resonance (MR) imaging properties are elucidated. The applications of the complexes for bioimaging applications of different bioactive species are demonstrated. The current challenges and potential future directions of these probes for applications in biological systems are also discussed.
检测生物系统中各种生物活性物质的波动和分布对于早期疾病诊断至关重要。基于金属配合物的探针因其独特优势，如高发光性、良好的光稳定性、大斯托克斯位移、低毒性和良好的生物相容性，在生物成像应用中备受关注。在本综述中，我们总结了近五年基于氧化还原活性过渡金属配合物的探针的发展情况，这些探针以铁、锰和铜等金属离子为基础，它们在生命中起着至关重要的作用，并且可以避免将外源金属引入生物系统。阐明了赋予这些配合物光学或磁共振（MR）成像特性的设计原则。展示了这些配合物在不同生物活性物质生物成像应用中的应用。还讨论了这些探针在生物系统应用中的当前挑战和潜在未来方向。
