Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, PR China; Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging (i(3)), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA.
Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, PR China.
Curr Opin Chem Biol. 2022 Feb;66:102097. doi: 10.1016/j.cbpa.2021.102097. Epub 2021 Nov 11.
Biological imaging and biosensing from subcellular/cellular level to whole body have enabled non-invasive visualisation of molecular events during various biological and pathological processes, giving great contributions to the rapid and impressive advances in chemical biology, drug discovery, disease diagnosis and prognosis. Optical imaging features a series of merits, including convenience, high resolution, good sensitivity, low cost and the absence of ionizing radiation. Among different luminescent probes, metal-based molecules offer unique promise in optical bioimaging and biosensing in vitro and in vivo, arising from their small sizes, strong luminescence, large Stokes shifts, long lifetimes, high photostability and tunable toxicity. In this review, we aim to highlight the design of metal-based molecular probes from the standpoint of synthetic chemistry in the last 2 years for optical imaging, covering d-block transition metal and lanthanide complexes and multimodal imaging agents.
从亚细胞/细胞水平到全身的生物成像和生物传感使人们能够在各种生物和病理过程中对分子事件进行非侵入性可视化，为化学生物学、药物发现、疾病诊断和预后的快速和显著进步做出了巨大贡献。光学成像是一种具有一系列优点的技术，包括方便、高分辨率、高灵敏度、低成本和无电离辐射。在不同的发光探针中，基于金属的分子在体外和体内的光学生物成像和生物传感中具有独特的应用前景，这是由于它们的尺寸小、发光强、Stokes 位移大、寿命长、光稳定性高和毒性可调。在这篇综述中，我们旨在从过去 2 年的合成化学角度强调设计基于金属的分子探针用于光学成像，涵盖 d 区过渡金属和镧系元素配合物以及多模态成像剂。
