Wang Qingqing, Yan Dong, Zheng Shuting, Li Min, Li Jialin, Fu Xiuyu, Fu Dandan, Hu Hua, Song Xiangfeng, Tian Zhongwei
Department of Dermatology, The First Affiliated Hospital of Xinxiang Medical University, Henan, Xinxiang, China.
Department of Microbiology, School of Basic Medical Sciences, Xinxiang Medical University, Henan, Xinxiang, China.
Indian J Dermatol. 2022 Mar-Apr;67(2):204. doi: 10.4103/ijd.ijd_79_22.
Psoriasis is a chronic skin disease characterized by hyperproliferation of keratinocytes and increased inflammation. Previous studies have detected the levels of cytokines in the serum of patients with psoriasis, yet few multi-cytokine combination studies have been reported.
The aim of the study was to compare the levels of cytokines in the serum between patients with psoriasis and healthy controls, elucidate which factors influence the psoriasis progression.
A total of 39 psoriasis patients and 30 healthy volunteers were enrolled. The venous blood was collected and the levels of 13 inflammatory cytokines were measured by human inflammation panel 1 kit. The severity of the disease was determined according to the psoriasis area and severity index (PASI) score.
Compared with healthy controls, the levels of nine cytokines (IFN-γ, TNF-α, IL-1β, IL-6, IL-10, IL-12P40, IL-18, IL-17A and IL-23) were significantly increased, while the level of MCP-1 decreased in psoriatic patients. In addition, except for MCP-1, IL-10 and IL-12P40, these cytokine levels were positively correlated with the PASI score. Furthermore, there were higher serum lever of IFN-γ, TNF-α, IL-1β, IL-6, IL-17A, IL-18 and IL-23 in active psoriasis than healthy controls and retrograde psoriasis.
Increased serum levels of IFN-γ, TNF-α, IL-1β, IL-6, IL-17A, IL-18 and IL-23 in psoriatic patients were associated with PASI and the stage of disease, which suggested that these cytokines play an important role in the pathogenesis of psoriasis. The detection of these cytokines can better observe the disease activity of psoriasis and optimize the treatment strategy.
银屑病是一种以角质形成细胞过度增殖和炎症增加为特征的慢性皮肤病。以往研究检测了银屑病患者血清中的细胞因子水平，但多细胞因子联合研究报道较少。
本研究旨在比较银屑病患者与健康对照者血清中细胞因子水平，阐明影响银屑病病情进展的因素。
共纳入39例银屑病患者和30名健康志愿者。采集静脉血，采用人类炎症检测试剂盒1检测13种炎症细胞因子水平。根据银屑病面积和严重程度指数（PASI）评分确定疾病严重程度。
与健康对照相比，银屑病患者9种细胞因子（IFN-γ、TNF-α、IL-1β、IL-6、IL-10、IL-12P40、IL-18、IL-17A和IL-23）水平显著升高，而MCP-1水平降低。此外，除MCP-1、IL-10和IL-12P40外，这些细胞因子水平与PASI评分呈正相关。此外，活动期银屑病患者血清中IFN-γ、TNF-α、IL-1β、IL-6、IL-17A、IL-18和IL-23水平高于健康对照和静止期银屑病患者。
银屑病患者血清中IFN-γ、TNF-α、IL-1β、IL-6、IL-17A、IL-18和IL-23水平升高与PASI及疾病分期相关，提示这些细胞因子在银屑病发病机制中起重要作用。检测这些细胞因子可更好地观察银屑病的疾病活动情况并优化治疗策略。
