Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Monterrey, Nuevo León, Mexico.
Laboratorio de Materiales Biotecnológicos Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, IMBICE-Conicet, Bernal, Buenos Aires, Argentina.
Int Wound J. 2022 Jan;19(1):100-113. doi: 10.1111/iwj.13602. Epub 2021 May 5.
Wound healing is a complex process of communication between growth factors, reactive species of oxygen, cells, signalling pathways, and cytokines in the extracellular matrix, in which growth factors are the key regulators. In humans, the main regulators of the cellular responses in wound healing are five growth factors, namely EGF, bFGF, VEGF, and TGF-β1. On the other hand, antioxidants such as astaxanthin, beta-carotene, epigallocatechin gallate, delphinidin, and curcumin have been demonstrated to stimulate cell proliferation, migration and angiogenesis, and control inflammation, to suggest a practical approach to design new strategies to treat non-healing cutaneous conditions. Based on the individual effects of growth factors and antioxidants, it may be envisioned that the use of both types of bioactives in wound healing formulations may have an additive or synergistic effect on the healing potential. This review addresses the effect of growth factors and antioxidants on wound healing-related processes. Furthermore, a prospective on their potential additive or synergistic effect on wound healing formulations, based on their individual effects, is presented. This may serve as a guide for the development of a new generation of wound healing formulations.
伤口愈合是一个涉及生长因子、活性氧物种、细胞、细胞外基质中的信号通路和细胞因子之间复杂交流的过程，其中生长因子是关键的调节因子。在人类中，细胞对伤口愈合反应的主要调节剂是五种生长因子，即表皮生长因子（EGF）、碱性成纤维细胞生长因子（bFGF）、血管内皮生长因子（VEGF）和转化生长因子-β1（TGF-β1）。另一方面，虾青素、β-胡萝卜素、表没食子儿茶素没食子酸酯、飞燕草素和姜黄素等抗氧化剂已被证明可刺激细胞增殖、迁移和血管生成，并控制炎症，这表明可以设计新的策略来治疗非愈合性皮肤疾病。基于生长因子和抗氧化剂的个体作用，可以想象，在伤口愈合配方中同时使用这两种生物活性物质可能对愈合潜力具有相加或协同作用。本综述讨论了生长因子和抗氧化剂对与伤口愈合相关的过程的影响。此外，还根据它们的个体作用，对它们在伤口愈合配方中的潜在相加或协同作用进行了展望。这可以作为开发新一代伤口愈合配方的指南。
