Turner P J, Young I F, Marley P B, Herrington R W, Schiff P
Dev Biol Stand. 1987;67:119-27.
Analysis of all clinical reactions (complaints) reported to CSL in the past decade has revealed that "hypotension syndrome" continues to be the predominant side effect of infusion of albumin solutions. Although the incidence of clinical reactions to albumin solutions reported to CSL is approximately 1 in every 20,000 bottles issued, the virtual elimination of PKA from SPPS has not reduced the number of adverse clinical reports received by CSL. It is concluded that factors other than PKA contamination are responsible for hypotensive effects during or after infusion of albumin solutions. Other possible causes of "hypotension syndrome" are discussed.
对过去十年间向CSL报告的所有临床反应（投诉）进行分析后发现，“低血压综合征”仍然是输注白蛋白溶液的主要副作用。虽然向CSL报告的白蛋白溶液临床反应发生率约为每发放20000瓶中有1例，但从单克隆抗体生产工艺中几乎消除PKA并没有减少CSL收到的不良临床报告数量。得出的结论是，除PKA污染外的其他因素是白蛋白溶液输注期间或之后出现低血压效应的原因。文中还讨论了“低血压综合征”的其他可能原因。
