Izreig Said, Hajek Michael, Edwards Heather A, Mehra Saral, Sasaki Clarence, Judson Benjamin L, Rahmati Rahmatullah W
Department of Surgery, Section of Otolaryngology Yale University School of Medicine New Haven Connecticut USA.
Yale Cancer Center New Haven Connecticut USA.
Laryngoscope Investig Otolaryngol. 2020 Nov 3;5(6):1079-1088. doi: 10.1002/lio2.469. eCollection 2020 Dec.
Head and neck squamous cell carcinoma (HNSCC) describes a set of malignancies of the head and neck that continue to inflict considerable morbidity and mortality. Because HNSCC often presents at an advanced stage, patients frequently undergo intensive multi-modal therapy with an intent to cure. Vitamin D is a precursor to the biologically active hormone calcitriol which governs bone and calcium physiology that is obtained from diet and UV-B exposure. Vitamin D is known to have pleiotropic effects on health and disease. In this review, we examine the role of vitamin D in cancer with emphasis on HNSCC and discuss potential avenues for further research that might better elucidate the role of vitamin D in the management of HNSCC.
A review of MEDLINE database indexed literature concerning the role and biology of vitamin D in HNSCC was conducted, with special consideration of recently published work and research involving immunobiology and HNSCC.
The available evidence suggests that vitamin D may play a role in protecting against HNSCC, particularly in persons who smoke, although conflicting and limited data exists. Promising initial work encourages the pursuit of further study.
The significant morbidity and mortality that HNSCC brings warrants continued research in available and safe interventions that improve patient outcomes. With the rise of immunotherapy as an effective modality for treatment, continued research of vitamin D as an adjunct in the treatment of HNSCC is supported.
头颈部鳞状细胞癌（HNSCC）是一组头颈部恶性肿瘤，其发病率和死亡率仍然很高。由于HNSCC常处于晚期，患者常接受强化多模式治疗以达到治愈目的。维生素D是生物活性激素骨化三醇的前体，骨化三醇调节骨骼和钙的生理功能，可通过饮食和紫外线B照射获得。维生素D对健康和疾病具有多效性作用。在本综述中，我们研究维生素D在癌症中的作用，重点是HNSCC，并讨论进一步研究的潜在途径，以更好地阐明维生素D在HNSCC治疗中的作用。
对MEDLINE数据库中关于维生素D在HNSCC中的作用和生物学的文献进行综述，特别考虑最近发表的涉及免疫生物学和HNSCC的研究。
现有证据表明，维生素D可能在预防HNSCC中发挥作用，尤其是在吸烟者中，尽管存在相互矛盾和有限的数据。有前景的初步研究鼓励进一步开展研究。
HNSCC带来的高发病率和死亡率值得继续研究可用且安全的干预措施以改善患者预后。随着免疫疗法作为一种有效治疗方式的兴起，支持继续研究维生素D作为HNSCC治疗辅助手段的作用。
