Department of Surgery, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland;
Department of Surgery, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
In Vivo. 2022 Sep-Oct;36(5):2287-2296. doi: 10.21873/invivo.12958.
BACKGROUND/AIM: The diagnostic accuracy (DA) for patients with acute pancreatitis (AcPa) has been rarely evaluated.
In the AcPa study group, there were 22 patients versus 1,311 patients in the non-AcPa group. The clinical history-taking variables (CHT) (n=22), clinical signs & tests details (CST) (n=14), and laboratory analyses (n=3) were recorded in each patient. Meta-analytical techniques were used to detect the summary sensitivity (Se) and specificity (Sp) estimates for each data set; CHT, CST, and diagnostic scores (DS).
In receiver operating characteristic (ROC) analysis, the area under curve (AUC) values for i) CHT, ii) CST, and iii) DS were as follows: i) AUC=0.640 (95%CI=0.550-0.730); ii) AUC=0.588 (95%CI=0.520-0.656), and iii) AUC=0.943 (95%CI=0.910-0.976). The differences between these AUC values (roccomp analysis) are as follows: i) versus ii) p=0.155; i) versus iii) p<0.0001; ii) versus iii) p<0.0001.
The new DS introduced in this study proved to be far superior to both symptoms and signs & tests in its DA for AcPa, as demonstrated by HSROC analysis.
背景/目的：急性胰腺炎（AcPa）患者的诊断准确性（DA）很少得到评估。
在 AcPa 研究组中，有 22 例患者，而非 AcPa 组有 1311 例患者。每位患者记录了临床病史采集变量（CHT）（n=22）、临床体征和检查细节（CST）（n=14）和实验室分析（n=3）。使用荟萃分析技术检测每个数据集的汇总敏感性（Se）和特异性（Sp）估计值；CHT、CST 和诊断评分（DS）。
在受试者工作特征（ROC）分析中，i）CHT、ii）CST 和 iii）DS 的曲线下面积（AUC）值如下：i）AUC=0.640（95%CI=0.550-0.730）；ii）AUC=0.588（95%CI=0.520-0.656），iii）AUC=0.943（95%CI=0.910-0.976）。这些 AUC 值之间的差异（roccomp 分析）如下：i）与 ii）p=0.155；i）与 iii）p<0.0001；ii）与 iii）p<0.0001。
本研究中引入的新 DS 在其对 AcPa 的 DA 方面证明远优于症状和体征与检查，这通过 HSROC 分析得到了证明。
