Department of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, Texas, United States of America.
Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, United States of America.
PLoS One. 2022 Sep 13;17(9):e0274492. doi: 10.1371/journal.pone.0274492. eCollection 2022.
Regular physical activity reduces the progression of several cancers and offers physical and mental health benefits for cancer survivors. However, many cancer survivors are not sufficiently active to achieve these health benefits. Possible biological mechanisms through which physical activity could affect cancer progression include reduced systemic inflammation and positive changes in metabolic markers. Chronic and acute hyperglycemia could have downstream effects on cell proliferation and tumorigenesis. One novel strategy to motivate cancer survivors to be more active is to provide personalized biological-based feedback that demonstrates the immediate positive impact of physical activity. Continuous glucose monitors (CGMs) have been used to demonstrate the acute beneficial effects of physical activity on insulin sensitivity and glucose metabolisms in controlled lab settings. Using personal data from CGMs to illustrate the immediate impact of physical activity on glucose patterns could be particularly relevant for cancer survivors because they are at a higher risk for developing type 2 diabetes (T2D). As a pilot project, this study aims to (1) test the preliminary effect of a remotely delivered physical activity intervention that incorporates personalized biological-based feedback on daily physical activity levels, and (2) explore the association between daily glucose patterns and cancer-related insulin pathway and inflammatory biomarkers in cancer survivors who are at high risk for T2D. We will recruit 50 insufficiently active, post-treatment cancer survivors who are at elevated risk for T2D. Participants will be randomly assigned into (1) a group that receives personalized biological feedback related to physical activity behaviors; and (2) a control group that receives standard educational material. The feasibility and preliminary efficacy of this wearable sensor-based, biofeedback-enhanced 12-week physical activity intervention will be evaluated. Data from this study will support the further refinement and enhancement of a more comprehensive remotely delivered physical activity intervention that targets cancer survivors. Trial registration: ClinicalTrials.gov Identifier: NCT05490641.
定期进行身体活动可减缓多种癌症的进展，并为癌症幸存者带来身心健康益处。然而，许多癌症幸存者的身体活动量不足，无法从中受益。身体活动可能影响癌症进展的可能生物学机制包括降低全身炎症和代谢标志物的积极变化。慢性和急性高血糖可能对细胞增殖和肿瘤发生产生下游影响。一种激励癌症幸存者更加活跃的新策略是提供个性化的基于生物学的反馈，展示身体活动的即时积极影响。连续血糖监测器 (CGM) 已被用于在受控的实验室环境中证明身体活动对胰岛素敏感性和葡萄糖代谢的急性有益影响。使用 CGM 的个人数据来说明身体活动对葡萄糖模式的即时影响对于癌症幸存者可能特别相关，因为他们患 2 型糖尿病 (T2D) 的风险更高。作为一个试点项目，本研究旨在：(1) 测试一种远程提供的身体活动干预措施的初步效果，该干预措施包含针对日常身体活动水平的个性化基于生物学的反馈；(2) 探索在患有 T2D 高风险的癌症幸存者中，每日血糖模式与癌症相关的胰岛素途径和炎症生物标志物之间的关联。我们将招募 50 名活动量不足、治疗后患有 T2D 高风险的癌症幸存者。参与者将被随机分配到以下两个组：(1) 接受与身体活动行为相关的个性化生物学反馈的组；(2) 接受标准教育材料的对照组。将评估这种基于可穿戴传感器的、生物反馈增强的 12 周身体活动干预措施的可行性和初步效果。这项研究的数据将支持进一步改进和增强针对癌症幸存者的更全面的远程身体活动干预措施。试验注册：ClinicalTrials.gov 标识符：NCT05490641。
