Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, You'anmen Wai, Fengtai District, 100069, Beijing, China.
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
Cardiovasc Diabetol. 2022 Sep 13;21(1):183. doi: 10.1186/s12933-022-01617-2.
Future risk of cardiovascular disease (CVD) and mortality is associated with cumulative amount TyG index (cumTyG) exposure, while whether time course of TyG accumulation modulates the risk remains unclear. This study sought to examine the associations of cumTyG index accumulation time course with the risk of CVD and all-cause mortality.
We enrolled 51,734 participants free of CVD and underwent three examinations at year 2006, 2008, and 2010. CumTyG from baseline to the third examination was calculated. Time course of cumTyG accumulation was calculated as the slope of TyG versus time from 2006 to 2010, or as splinting the overall TyG index accumulation into early (cumTyG) and late accumulation (cumTyG). Participants were categorized by the combination of cumTyG < or ≥ median (34.44 × years) and a negative or positive TyG slope.
During a median follow-up of 9.04 years, we identified 3,602 incident CVD cases and 3,165 deaths. The risk of CVD and all-cause mortality increased with decreased TyG slope, the corresponding adjusted hazard ratio (aHR) with 95% confidence interval (CI) was 1.11 (1.04-1.19) and 1.18 (1.10-1.26) for patients with a negative TyG slope, respectively. Consistently, a later accumulation of TyG index was not associated with the risk of CVD and all-cause mortality after adjustment for an early accumulation. When considering the combination of cumTyG index and time course, participants with a cumTyG ≥ median and a negative TyG slope had elevated risk of CVD (aHR, 1.37; 95% CI, 1.24-1.51) and all-cause mortality (aHR, 1.28; 95% CI, 1.15-1.43). Additionally, the association was more prominent in young adults.
Early TyG index accumulation resulted in a greater risk of CVD and all-cause mortality than later TyG later accumulation with the same overall cumulative exposure, emphasizing the importance of optimal TyG index control earlier in life.
未来心血管疾病（CVD）和死亡率的风险与 TyG 指数（cumTyG）的累积暴露量有关，而 TyG 积累的时间进程是否调节风险尚不清楚。本研究旨在探讨 cumTyG 指数积累时间进程与 CVD 和全因死亡率风险之间的关联。
我们纳入了 51734 名无 CVD 的参与者，并在 2006 年、2008 年和 2010 年进行了三次检查。从基线到第三次检查计算 cumTyG。TyG 与 2006 年至 2010 年时间的斜率计算 cumTyG 积累的时间进程，或将总体 TyG 指数积累划分为早期（cumTyG）和晚期（cumTyG）积累。根据 cumTyG<或≥中位数（34.44×年）和 TyG 斜率的正负将参与者分为两组。
在中位数为 9.04 年的随访期间，我们确定了 3602 例 CVD 事件和 3165 例死亡。CVD 和全因死亡率的风险随着 TyG 斜率的降低而增加，相应的校正后危险比（aHR）和 95%置信区间（CI）分别为 1.11（1.04-1.19）和 1.18（1.10-1.26）对于 TyG 斜率为负的患者。同样，在调整早期积累后，TyG 指数的后期积累与 CVD 和全因死亡率的风险无关。当考虑 cumTyG 指数和时间进程的组合时，cumTyG≥中位数且 TyG 斜率为负的参与者 CVD（aHR，1.37；95%CI，1.24-1.51）和全因死亡率（aHR，1.28；95%CI，1.15-1.43）的风险增加。此外，这种关联在年轻成年人中更为明显。
与相同的总体累积暴露相比，早期 TyG 指数的积累导致 CVD 和全因死亡率的风险高于后期 TyG 指数的积累，这强调了在生命早期优化 TyG 指数控制的重要性。
Zotero 插件
