NMPA Key Laboratory for Clinical Research and Evaluation of Traditional Chinese Medicine, Xiyuan Hospital, China Academy of Chinese Medicine Sciences, 1 Xiyuan Caochang, Haidian District, Beijing, 100091, China.
National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medicine Sciences, 1 Xiyuan Caochang, Haidian District, Beijing, 100091, China.
Sci Rep. 2023 Sep 30;13(1):16478. doi: 10.1038/s41598-023-43512-0.
Despite a wealth of research linking the triglyceride glucose index (TyG index) to metabolic diseases. However, little evidence links the TyG index to all-cause or CVD mortality in middle-aged and elderly individuals with type 2 diabetes (T2D). This study analyzed data from 2998 patients with T2D who participated in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. The TyG index and mortality in middle-aged and elderly T2D patients were investigated using Cox regression models. The nonlinear association between the TyG index and mortality can be understood with the help of a restricted cubic spline (RCS). During a median follow-up period of 82 months, 883 fatalities were observed from all causes and 265 from CVD. The TyG index was found to have a U-shaped relationship with all-cause and CVD mortality in T2D, with cutoffs of 8.95 and 9, respectively, according to the RCS. After controlling for other factors, an increase of 1 unit in the TyG index was related to an increase of 33% in all-cause mortality and 50% in CVD mortality when TyG was ≥ 8.95 and 9. When TyG < 8.95 and 9, with the change in the TyG index, the change in all-cause and CVD death was insignificant. Patients with T2D who are middle-aged or older, especially elderly patients, have higher TyG levels associated with increased mortality. In middle-aged and elderly patients with T2D, the TyG index may predict the probability of death from any cause and death from CVD.
尽管有大量研究将甘油三酯-葡萄糖指数（TyG 指数）与代谢疾病联系起来。然而，几乎没有证据表明 TyG 指数与中年和老年 2 型糖尿病（T2D）患者的全因或心血管疾病（CVD）死亡率有关。本研究分析了 2018 年参加全国健康和营养检查调查（NHANES）的 2998 例 T2D 患者的数据。使用 Cox 回归模型研究了 TyG 指数与中年和老年 T2D 患者死亡率之间的关系。受限立方样条（RCS）有助于理解 TyG 指数与死亡率之间的非线性关系。在中位随访 82 个月期间，观察到 883 例全因死亡和 265 例 CVD 死亡。RCS 显示，TyG 指数与 T2D 患者的全因和 CVD 死亡率呈 U 形关系，截断值分别为 8.95 和 9。在控制其他因素后，TyG 指数每增加 1 单位，当 TyG 指数≥8.95 和 9 时，全因死亡率增加 33%，CVD 死亡率增加 50%。当 TyG＜8.95 和 9 时，随着 TyG 指数的变化，全因和 CVD 死亡的变化不显著。中年或老年 T2D 患者，尤其是老年患者，TyG 水平较高与死亡率增加相关。在中年和老年 T2D 患者中，TyG 指数可能预测任何原因引起的死亡和 CVD 引起的死亡的概率。
