甘油三酯-葡萄糖指数预测慢性肾脏病患者的主要不良心血管事件。
Triglyceride-glucose index predicts major adverse cardiovascular events in patients with chronic kidney disease.
机构信息
Department of Internal Medicine, Wenfeng District Xiguan Subdistrict Office Community Health Center, Anyang, China.
Hebei Medical University, Shijiazhuang, China.
出版信息
Int Urol Nephrol. 2024 Aug;56(8):2793-2802. doi: 10.1007/s11255-024-04005-9. Epub 2024 Mar 27.
BACKGROUND AND PURPOSE
Triglyceride-glucose (TyG) index has been regarded as a reliable surrogate marker of insulin resistance for predicting cardiovascular outcomes. The current study aimed to explore the associations between TyG index with major adverse cardiovascular events (MACE) in patients with chronic kidney disease (CKD).
METHODS/PATIENTS: 13,517 patients with chronic kidney disease (CKD) from the Kailuan study were included. Patients were divided into quartiles according to the TyG index. The outcomes were MACE, including acute myocardial infarction (AMI) and ischemic stroke (IS). The association between TyG index and the risk of MACE was analyzed by Cox regression models.
RESULTS
During 13.87-year follow-up, a total 1356 MACEs occurred. Multivariable Cox proportional-hazards analyses showed that a higher TyG index quartile was associated with an elevated risk of MACE.
CONCLUSIONS
TyG index is significantly related to MACE in patients with CKD. TyG index can be regarded as a novel predictor of MACE for patients with CKD.
背景与目的
甘油三酯-葡萄糖（TyG）指数已被视为预测心血管结局的胰岛素抵抗的可靠替代标志物。本研究旨在探讨慢性肾脏病（CKD）患者 TyG 指数与主要不良心血管事件（MACE）之间的关系。
方法/患者：纳入了来自开滦研究的 13517 例慢性肾脏病（CKD）患者。根据 TyG 指数将患者分为四分位组。结局为 MACE，包括急性心肌梗死（AMI）和缺血性卒中（IS）。采用 Cox 回归模型分析 TyG 指数与 MACE 风险之间的关系。
结果
在 13.87 年的随访期间，共发生了 1356 例 MACE。多变量 Cox 比例风险分析表明，较高的 TyG 指数四分位组与 MACE 风险升高相关。
结论
TyG 指数与 CKD 患者的 MACE 显著相关。TyG 指数可作为 CKD 患者 MACE 的新型预测指标。
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