Department of Dermatology, University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
Clin Exp Dermatol. 2022 Dec;47(12):2123-2129. doi: 10.1111/ced.15400. Epub 2022 Oct 26.
Oestrogen plays a vital role in maintaining a normal vulvovaginal epithelium, vaginal lubrication, as well as a healthy microbiome to ensure an acidic pH. The decrease in oestrogen levels in women going through menopause results in both physiological and physical changes of the genitourinary system, and more specifically the vulva. We conducted a literature review on the effects of low oestrogen levels on the physiology and function of the vulva and the vulvovaginal epithelium. 'Genitourinary syndrome of menopause' (GSM) is the term used to describe the signs and symptoms of a low oestrogen state. The symptoms and signs of GSM can overlap or coexist with other vulval dermatoses. Expert opinion is needed to diagnose and manage vulval dermatoses in menopause. This article will discuss the signs and symptoms of GSM, as well as the different management options available. Other vulval dermatoses that can be affected by hypo-oestrogenism are also reviewed.
雌激素对维持正常的外阴阴道上皮、阴道润滑以及健康的微生物群以确保酸性 pH 值起着至关重要的作用。经历更年期的女性体内雌激素水平下降会导致生殖泌尿系统的生理和物理变化，更具体地说是外阴。我们对低雌激素水平对外阴和外阴阴道上皮的生理和功能的影响进行了文献回顾。“绝经后生殖泌尿系统综合征”（GSM）是用来描述低雌激素状态的体征和症状的术语。GSM 的症状和体征可能与其他外阴皮肤病重叠或并存。需要专家意见来诊断和管理更年期外阴皮肤病。本文将讨论 GSM 的体征和症状，以及可用的不同管理选择。还回顾了可能受到低雌激素影响的其他外阴皮肤病。
