Enders G, Jonatha W
Infection. 1987 May-Jun;15(3):162-4. doi: 10.1007/BF01646038.
The results of prenatal diagnosis of fetal rubella infection by specific IgM antibody detection in fetal infection by specific IgM antibody detection in fetal blood obtained in the 21st to 23rd weeks of pregnancy of women with different types of rubella problems during pregnancy (categorised in four groups) showed that in 28 of 31 cases the diagnosis apparently assisted in the correct management of the pregnancy. However, in two cases with negative IgM findings in the fetal blood, children with rubella embryopathy were born, and in one case with positive IgM antibody findings, the child was infected but healthy. From this experience we recommend that in all cases of symptomatic rubella infection in the first 12 weeks, termination of pregnancy should be considered without prenatal diagnosis. Prenatal diagnosis, if considered at all, should be limited to "symptomless" acute rubella infection and reinfection in the first 12 weeks and to symptomatic rubella infection in the 12th to 17th weeks of pregnancy.
通过检测孕期不同风疹问题（分为四组）的孕妇在妊娠第21至23周采集的胎儿血液中的特异性IgM抗体，对胎儿风疹感染进行产前诊断的结果显示，在31例病例中有28例的诊断显然有助于对妊娠进行正确管理。然而，有2例胎儿血液中IgM检测结果为阴性的病例，出生了患有风疹胚胎病的儿童，还有1例IgM抗体检测结果为阳性的病例，孩子虽受感染但健康。根据这一经验，我们建议，对于妊娠前12周内所有有症状的风疹感染病例，应考虑终止妊娠，无需进行产前诊断。如果要考虑进行产前诊断，应仅限于妊娠前12周内“无症状”的急性风疹感染和再感染，以及妊娠第12至17周内有症状的风疹感染。
