Prenatal diagnosis of intrauterine rubella.

The results of prenatal diagnosis of fetal rubella infection by specific IgM antibody detection in fetal infection by specific IgM antibody detection in fetal blood obtained in the 21st to 23rd weeks of pregnancy of women with different types of rubella problems during pregnancy (categorised in four groups) showed that in 28 of 31 cases the diagnosis apparently assisted in the correct management of the pregnancy. However, in two cases with negative IgM findings in the fetal blood, children with rubella embryopathy were born, and in one case with positive IgM antibody findings, the child was infected but healthy. From this experience we recommend that in all cases of symptomatic rubella infection in the first 12 weeks, termination of pregnancy should be considered without prenatal diagnosis. Prenatal diagnosis, if considered at all, should be limited to "symptomless" acute rubella infection and reinfection in the first 12 weeks and to symptomatic rubella infection in the 12th to 17th weeks of pregnancy.