Department of Computer Science and Engineering, Islamic University of Science and Techonology Kashmir, Awantipora, 192122, J&K, India.
Department of Computer Science, Islamic University of Science and Techonology Kashmir, Awantipora, 192122, J&K, India.
Comput Biol Med. 2022 Oct;149:106073. doi: 10.1016/j.compbiomed.2022.106073. Epub 2022 Aug 31.
Breast Cancer (BC) is the most commonly diagnosed cancer and second leading cause of mortality among women. About 1 in 8 US women (about 13%) will develop invasive BC throughout their lifetime. Early detection of this life-threatening disease not only increases the survival rate but also reduces the treatment cost. Fortunately, advancements in radiographic imaging like "Mammograms", "Computed Tomography (CT)", "Magnetic Resonance Imaging (MRI)", "3D Mammography", and "Histopathological Imaging (HI)" have made it feasible to diagnose this life-taking disease at an early stage. However, the analysis of radiographic images and Histopathological images is done by experienced radiologists and pathologists, respectively. The process is not only costly but also error-prone. Over the last ten years, Computer Vision and Machine Learning (ML) have transformed the world in every way possible. Deep learning (DL), a subfield of ML has shown outstanding results in a variety of fields, particularly in the biomedical industry, because of its ability to handle large amounts of data. DL techniques automatically extract the features by analyzing the high dimensional and correlated data efficiently. The potential and ability of DL models have also been utilized and evaluated in the identification and prognosis of BC, utilizing radiographic and Histopathological images, and have performed admirably. However, AI has shown good claims in retrospective studies only. External validations are needed for translating these cutting-edge AI tools as a clinical decision maker. The main aim of this research work is to present the critical analysis of the research and findings already done to detect and classify BC using various imaging modalities including "Mammography", "Histopathology", "Ultrasound", "PET/CT", "MRI", and "Thermography". At first, a detailed review of the past research papers using Machine Learning, Deep Learning and Deep Reinforcement Learning for BC classification and detection is carried out. We also review the publicly available datasets for the above-mentioned imaging modalities to make future research more accessible. Finally, a critical discussion section has been included to elaborate open research difficulties and prospects for future study in this emerging area, demonstrating the limitations of Deep Learning approaches.
乳腺癌(BC)是最常见的癌症,也是女性死亡的第二大主要原因。大约每 8 名美国女性(约 13%)在其一生中都会患上浸润性 BC。这种危及生命的疾病的早期发现不仅提高了生存率,还降低了治疗成本。幸运的是,影像学的进步,如“乳房 X 光摄影”、“计算机断层扫描(CT)”、“磁共振成像(MRI)”、“三维乳房 X 光摄影”和“组织病理学成像(HI)”,使得在早期阶段诊断这种危及生命的疾病成为可能。然而,放射图像和组织病理学图像的分析分别由有经验的放射科医生和病理学家进行。这个过程不仅昂贵,而且容易出错。在过去的十年中,计算机视觉和机器学习(ML)已经以各种可能的方式改变了世界。深度学习(DL)作为 ML 的一个子领域,因其能够处理大量数据,在各个领域,特别是在生物医学行业,都取得了出色的成果。DL 技术通过分析高维相关数据,自动提取特征。DL 模型的潜力和能力也被用于识别和预测 BC,利用放射学和组织病理学图像,并取得了优异的效果。然而,人工智能仅在回顾性研究中显示出良好的效果。需要进行外部验证,将这些前沿的 AI 工具转化为临床决策者。这项研究工作的主要目的是对已经使用各种成像方式(包括“乳房 X 光摄影”、“组织病理学”、“超声”、“PET/CT”、“MRI”和“热成像”)进行 BC 检测和分类的研究和发现进行批判性分析。首先,我们对使用机器学习、深度学习和深度强化学习进行 BC 分类和检测的过去研究论文进行了详细的回顾。我们还回顾了上述成像方式的公开数据集,以使未来的研究更容易进行。最后,我们包括了一个批判性讨论部分,详细阐述了这个新兴领域的开放研究难点和未来研究的前景,展示了深度学习方法的局限性。
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