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同种异体骨打压植骨在股骨近端良性病变治疗中的作用

Role of impaction bone grafting of allografts in the management of benign lesions of the proximal femur.

作者信息

Rajasekaran Raja Bhaskara, Jayaramaraju Dheenadhayalan, Palanisami Dhanasekara Raja, Agraharam Devendra, Thippeswamy Pushpa Bhari, Rajasekaran Shanmuganathan

机构信息

Department of Orthopaedics & Trauma, Ganga Medical Centre & Hospitals Pvt. Ltd, 313, Mettupalayam Road, Coimbatore, India.

Department of Radiology, Ganga Medical Centre & Hospitals Pvt. Ltd, 313, Mettupalayam Road, Coimbatore, India.

出版信息

J Orthop. 2022 Sep 1;34:189-195. doi: 10.1016/j.jor.2022.08.025. eCollection 2022 Nov-Dec.

Abstract

PURPOSE OF STUDY

The use of allografts to reconstruct benign lesions of the proximal femur after curettage has seldom been reported. We report our experience of impaction bone grafting of only allografts combined with osteosynthesis to manage benign lesions involving the proximal femur.

MATERIALS AND METHODS

Between 2013 and 2019, 35 patients of a mean age of 23.8 years (14-41) who had a biopsy proven benign pathology and a median pre-operative Mirels' score of 9 (8-11) were managed using extended curettage, impaction bone grafting of allografts combined with osteosynthesis through a lateral approach. Radiographs were assessed to see for any recurrence at follow-ups, and functional outcomes were assessed using Musculoskeletal Tumour Society (MSTS) score and Harris hip score (HHS).

RESULTS

At a mean follow-up was 41.5 months (23-80), patients demonstrated favorable functional outcomes with a mean MSTS of 28.3 (18-30) and a mean HHS of 94.3 (66-100) at the last follow-up. Two cases (GCT = 1; fibrous dysplasia = 1) had a recurrence of disease. Allografts demonstrated a particular integration pattern on radiographs that involved an intermediate period of lucency followed by consolidation and integration with the parent bone.

CONCLUSION

Impaction grafting of allografts in benign lesions of the proximal femur allows adequate bony consolidation of the cavity after extended curettage and can be effectively used as a permanent solution to manage such lesions in most cases. The intermediate period of lucency seen on radiographs must not be confused for recurrence, and patients must be followed up continuously.

STUDY DESIGN

Retrospective Case Series.

LEVEL OF EVIDENCE

Level IV.

摘要

研究目的

刮除术后使用同种异体骨重建股骨近端良性病变的情况鲜有报道。我们报告了仅使用同种异体骨打压植骨联合接骨术治疗累及股骨近端的良性病变的经验。

材料与方法

2013年至2019年间,对35例平均年龄23.8岁(14 - 41岁)、活检证实为良性病理且术前Mirels评分中位数为9(8 - 11)的患者,采用扩大刮除、同种异体骨打压植骨联合通过外侧入路的接骨术进行治疗。通过X线片评估随访时有无复发情况,并使用肌肉骨骼肿瘤学会(MSTS)评分和Harris髋关节评分(HHS)评估功能结果。

结果

平均随访41.5个月(23 - 80个月),患者功能结果良好,末次随访时MSTS平均评分为28.3(18 - 30),HHS平均评分为94.3(66 - 100)。2例(骨巨细胞瘤 = 1例;骨纤维发育不良 = 1例)疾病复发。同种异体骨在X线片上显示出一种特殊的整合模式,即中间有一段透亮期,随后是骨痂形成并与宿主骨整合。

结论

股骨近端良性病变的同种异体骨打压植骨可在扩大刮除术后使骨腔充分骨愈合,在大多数情况下可有效用作治疗此类病变的永久性解决方案。X线片上出现的中间透亮期不应被误认为是复发,必须对患者进行持续随访。

研究设计

回顾性病例系列。

证据级别

四级。

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