• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

烟酰胺单核苷酸通过调节肠道微生物群维持肠道稳态。

NMN Maintains Intestinal Homeostasis by Regulating the Gut Microbiota.

作者信息

Huang Pan, Jiang Anqi, Wang Xuxin, Zhou Yan, Tang Weihong, Ren Caifang, Qian Xin, Zhou Zhengrong, Gong Aihua

机构信息

School of Medicine, Jiangsu University, Zhenjiang, China.

出版信息

Front Nutr. 2021 Jul 29;8:714604. doi: 10.3389/fnut.2021.714604. eCollection 2021.

DOI:10.3389/fnut.2021.714604
PMID:34395502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8358781/
Abstract

The aim of this study was to determine the effects of long-term Nicotinamide mononucleotide (NMN) treatment on modulating gut microbiota diversity and composition, as well as its association with intestinal barrier function. In this study, C57BL/6J mice were fed different concentrations of NMN, and their feces were collected for detection of 16S rDNA and non-targeted metabolites to explore the effects of NMN on intestinal microbiota and metabolites. The results revealed that NMN increased the abundance of butyric acid-producing bacteria (Ruminococcae_UCG-014 and Prevotellaceae_NK3B31_group) and other probiotics (Akkermansia muciniphila), while the abundance of several harmful bacteria (Bilophila and Oscillibacter) were decreased after NMN treatment. Meanwhile, the level of bile acid-related metabolites in feces from the G1 group (0.1 mg/ml) was significantly increased compared to the control group, including cholic acid, taurodeoxycholic acid, taurocholic acid, glycocholic acid, and tauro-β-muricholic acid. In addition, long-term NMN treatment affected the permeability of the intestinal mucosa. The number of goblet cells and mucus thickness increased, as well as expression of tight junction protein. These results demonstrate that NMN reduced intestinal mucosal permeability and exerts a protective effect on the intestinal tract. This study lays the foundation for exploring NMN's utility in clinical research.

摘要

本研究的目的是确定长期烟酰胺单核苷酸（NMN）治疗对调节肠道微生物群多样性和组成的影响，以及其与肠道屏障功能的关联。在本研究中，给C57BL/6J小鼠喂食不同浓度的NMN，并收集它们的粪便用于检测16S rDNA和非靶向代谢物，以探索NMN对肠道微生物群和代谢物的影响。结果显示，NMN增加了产丁酸细菌（瘤胃球菌_UCG-014和普雷沃氏菌科_NK3B31组）和其他益生菌（嗜黏蛋白阿克曼氏菌）的丰度，而NMN处理后几种有害细菌（嗜胆菌属和颤杆菌属）的丰度降低。同时，与对照组相比，G1组（0.1 mg/ml）粪便中胆汁酸相关代谢物的水平显著升高，包括胆酸、牛磺去氧胆酸、牛磺胆酸、甘氨胆酸和牛磺-β-鼠胆酸。此外，长期NMN治疗影响肠黏膜的通透性。杯状细胞数量和黏液厚度增加，紧密连接蛋白的表达也增加。这些结果表明，NMN降低了肠黏膜通透性，并对肠道发挥保护作用。本研究为探索NMN在临床研究中的效用奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/874efc08e3f0/fnut-08-714604-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/a7578928c798/fnut-08-714604-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/40c427e68ebd/fnut-08-714604-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/acbfb7004c94/fnut-08-714604-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/72262b049654/fnut-08-714604-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/6c6eba6cffd9/fnut-08-714604-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/d4bb1a288eb7/fnut-08-714604-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/6459482fba35/fnut-08-714604-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/20099d7f90ed/fnut-08-714604-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/c352a6bc7a89/fnut-08-714604-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/cebb0890cfb1/fnut-08-714604-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/874efc08e3f0/fnut-08-714604-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/a7578928c798/fnut-08-714604-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/40c427e68ebd/fnut-08-714604-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/acbfb7004c94/fnut-08-714604-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/72262b049654/fnut-08-714604-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/6c6eba6cffd9/fnut-08-714604-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/d4bb1a288eb7/fnut-08-714604-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/6459482fba35/fnut-08-714604-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/20099d7f90ed/fnut-08-714604-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/c352a6bc7a89/fnut-08-714604-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/cebb0890cfb1/fnut-08-714604-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5716/8358781/874efc08e3f0/fnut-08-714604-g0011.jpg

相似文献

1
NMN Maintains Intestinal Homeostasis by Regulating the Gut Microbiota.烟酰胺单核苷酸通过调节肠道微生物群维持肠道稳态。
Front Nutr. 2021 Jul 29;8:714604. doi: 10.3389/fnut.2021.714604. eCollection 2021.
2
NMN alleviates radiation-induced intestinal fibrosis by modulating gut microbiota.NMN 通过调节肠道微生物群缓解辐射诱导的肠道纤维化。
Int J Radiat Biol. 2023;99(5):823-834. doi: 10.1080/09553002.2023.2145029. Epub 2022 Nov 16.
3
Treatment of inflammatory bowel disease: Potential effect of NMN on intestinal barrier and gut microbiota.炎症性肠病的治疗：烟酰胺单核苷酸对肠道屏障和肠道微生物群的潜在影响。
Curr Res Food Sci. 2022 Sep 5;5:1403-1411. doi: 10.1016/j.crfs.2022.08.011. eCollection 2022.
4
Disruption of the Intestinal Mucosal Barrier Induced by High Fructose and Restraint Stress Is Regulated by the Intestinal Microbiota and Microbiota Metabolites.高果糖和束缚应激诱导的肠道黏膜屏障破坏受肠道微生物群及其代谢产物调控。
Microbiol Spectr. 2023 Jan 31;11(2):e0469822. doi: 10.1128/spectrum.04698-22.
5
β-Nicotinamide mononucleotide supplementation prolongs the lifespan of prematurely aged mice and protects colon function in ageing mice.β-烟酰胺单核苷酸补充剂可延长早衰小鼠的寿命并保护衰老小鼠的结肠功能。
Food Funct. 2024 Mar 18;15(6):3199-3213. doi: 10.1039/d3fo05221d.
6
Nicotinamide mononucleotide improves the Alzheimer's disease by regulating intestinal microbiota.烟酰胺单核苷酸通过调节肠道微生物群改善阿尔茨海默病。
Biochem Biophys Res Commun. 2023 Aug 30;670:27-35. doi: 10.1016/j.bbrc.2023.05.075. Epub 2023 May 29.
7
In vitro digestion under simulated saliva, gastric and small intestinal conditions and fermentation of nicotinamide mononucleotide, and its effects on the gut microbiota.在模拟唾液、胃和小肠条件下的体外消化以及烟酰胺单核苷酸的发酵，及其对肠道微生物群的影响。
Food Res Int. 2024 Feb;177:113779. doi: 10.1016/j.foodres.2023.113779. Epub 2023 Nov 26.
8
New strain of alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism.新型菌株通过调节肠道微生物群和短链脂肪酸代谢来缓解乙醇引起的肝损伤。
World J Gastroenterol. 2020 Oct 28;26(40):6224-6240. doi: 10.3748/wjg.v26.i40.6224.
9
Stachyose increases intestinal barrier through Akkermansia muciniphila and reduces gut inflammation in germ-free mice after human fecal transplantation.棉子糖通过阿克曼氏菌和减少无菌小鼠肠道炎症增加肠屏障在人类粪便移植后。
Food Res Int. 2020 Nov;137:109288. doi: 10.1016/j.foodres.2020.109288. Epub 2020 May 15.
10
Fecal metabonomics combined with 16S rRNA gene sequencing to analyze the changes of gut microbiota in rats with kidney-yang deficiency syndrome and the intervention effect of You-gui pill.基于粪便代谢组学联合 16S rRNA 基因测序分析肾阳虚证大鼠肠道菌群变化及右归丸的干预作用
J Ethnopharmacol. 2019 Nov 15;244:112139. doi: 10.1016/j.jep.2019.112139. Epub 2019 Aug 8.

引用本文的文献

1
β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD/SIRT1 signaling pathways.β-烟酰胺单核苷酸通过激活NAD/SIRT1信号通路减轻小鼠模型中的酒精性肝损伤。
Hereditas. 2025 Aug 16;162(1):161. doi: 10.1186/s41065-025-00529-x.
2
Curcumin Ameliorates DSS-Induced Colitis in Mice Through Modulation of Gut Microbiota and Metabolites.姜黄素通过调节肠道微生物群和代谢产物改善右旋糖酐硫酸钠诱导的小鼠结肠炎。
Life (Basel). 2025 Jul 21;15(7):1153. doi: 10.3390/life15071153.
3
Microbiome-based therapeutics towards healthier aging and longevity.

本文引用的文献

1
Physiology and Physical Chemistry of Bile Acids.胆汁酸的生理学和物理化学。
Int J Mol Sci. 2021 Feb 10;22(4):1780. doi: 10.3390/ijms22041780.
2
Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology.靶向肠肝胆汁盐循环的四大支柱：遗传学和药理学的启示。
Hepatology. 2021 Jun;73(6):2577-2585. doi: 10.1002/hep.31651. Epub 2021 May 24.
3
Genome sequencing of cold-adapted Planococcus bacterium isolated from traditional shrimp paste and protease identification.从传统虾酱中分离的耐冷节杆菌的基因组测序和蛋白酶鉴定。
基于微生物群的疗法促进更健康的衰老和长寿。
Genome Med. 2025 Jul 1;17(1):75. doi: 10.1186/s13073-025-01493-x.
4
Biological properties, synthetic pathways and anti-aging mechanisms of nicotinamide mononucleotide (NMN): Research progress and challenges.烟酰胺单核苷酸（NMN）的生物学特性、合成途径及抗衰老机制：研究进展与挑战
Biogerontology. 2025 Jun 23;26(4):124. doi: 10.1007/s10522-025-10270-7.
5
Changes in the metabolome, lipidomein, and gut microbiota in Behçet's disease.白塞病中代谢组、脂质组和肠道微生物群的变化。
Front Cell Dev Biol. 2025 Mar 28;13:1530996. doi: 10.3389/fcell.2025.1530996. eCollection 2025.
6
Variation of Meat Quality and Relationship to Gut Microbiota Among Different Pig Breeds.不同猪种间肉质变化及其与肠道微生物群的关系
Microb Biotechnol. 2025 Apr;18(4):e70139. doi: 10.1111/1751-7915.70139.
7
Astragalus polysaccharide mitigates Eimeria tenella-induced damage in laying chicks by modulating immunity, inflammation, and intestine barrier.黄芪多糖通过调节免疫、炎症和肠道屏障减轻柔嫩艾美耳球虫对蛋鸡的损伤。
J Anim Sci. 2025 Jan 4;103. doi: 10.1093/jas/skaf080.
8
Comparative analysis of gut microbiota in healthy and diarrheic foals.健康和腹泻马驹肠道微生物群的比较分析。
Microbiol Spectr. 2025 Mar 19;13(5):e0087124. doi: 10.1128/spectrum.00871-24.
9
Colorectal cancer in Lynch syndrome families: consequences of gene germline mutations and the gut microbiota.林奇综合征家族中的结直肠癌：基因种系突变与肠道微生物群的影响
Orphanet J Rare Dis. 2025 Jan 18;20(1):30. doi: 10.1186/s13023-025-03543-4.
10
Effect of folpet on hypoglycaemia, intestinal microbiota, and drug resistance genes in mice.灭菌丹对小鼠低血糖、肠道微生物群及耐药基因的影响。
BMC Microbiol. 2025 Jan 9;25(1):11. doi: 10.1186/s12866-024-03725-3.
J Sci Food Agric. 2021 Jun;101(8):3225-3236. doi: 10.1002/jsfa.10952. Epub 2020 Dec 5.
4
Sturgeon hydrolysates alleviate DSS-induced colon colitis in mice by modulating NF-κB, MAPK, and microbiota composition.鲟鱼水解产物通过调节NF-κB、MAPK和微生物群组成来减轻小鼠中由葡聚糖硫酸钠诱导的结肠结肠炎。
Food Funct. 2020 Aug 1;11(8):6987-6999. doi: 10.1039/c9fo02772f. Epub 2020 Jul 23.
5
Absorption, metabolism, and bioactivity of vitexin: recent advances in understanding the efficacy of an important nutraceutical.牡荆素的吸收、代谢和生物活性：了解一种重要的营养保健品功效的最新进展。
Crit Rev Food Sci Nutr. 2021;61(6):1049-1064. doi: 10.1080/10408398.2020.1753165. Epub 2020 Apr 15.
6
Vitexin ameliorates high fat diet-induced obesity in male C57BL/6J mice via the AMPKα-mediated pathway.牡荆素通过 AMPKα 介导的途径改善高脂饮食诱导的雄性 C57BL/6J 小鼠肥胖。
Food Funct. 2019 Apr 1;10(4):1940-1947. doi: 10.1039/c9fo00148d. Epub 2019 Mar 15.
7
Comparative metabolomics reveals the metabolic variations between two endangered Taxus species (T. fuana and T. yunnanensis) in the Himalayas.比较代谢组学揭示了喜马拉雅山脉两种濒危红豆杉物种（中华红豆杉和云南红豆杉）之间的代谢差异。
BMC Plant Biol. 2018 Sep 17;18(1):197. doi: 10.1186/s12870-018-1412-4.
8
Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy.短链脂肪酸通过抑制NLRP3炎性小体和自噬对肠道屏障功能表现出刺激和保护作用。
Cell Physiol Biochem. 2018;49(1):190-205. doi: 10.1159/000492853. Epub 2018 Aug 23.
9
Oxyresveratrol stimulates mucin production in an NAD-dependent manner in human intestinal goblet cells.氧代白藜芦醇以 NAD 依赖的方式刺激人肠道杯状细胞黏蛋白的产生。
Food Chem Toxicol. 2018 Aug;118:880-888. doi: 10.1016/j.fct.2018.06.039. Epub 2018 Jun 20.
10
The human gut microbiota: Metabolism and perspective in obesity.人类肠道微生物群：肥胖症中的代谢和前景。
Gut Microbes. 2018 Jul 4;9(4):308-325. doi: 10.1080/19490976.2018.1465157. Epub 2018 May 24.