Kojiri K, Nakajima S, Suzuki H, Okura A, Suda H
New Drug Discovery Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Japan.
J Antibiot (Tokyo). 1993 Dec;46(12):1799-803. doi: 10.7164/antibiotics.46.1799.
New antitumor substance, designated BE-18591, was isolated from the culture broth of a streptomycete, strain BA18591. The active principle was extracted from mycelium by methanol and purified by silica gel chromatography. BE-18591 inhibited the growth of MKN-45 human stomach cancer cell line as well as P388 cell line. In in vivo experiments, BE-18591 inhibited the growth of Ehrlich ascites tumor.BE-18591 showed antimicrobial activity against Gram-positive and some Gram-negative bacteria.
从链霉菌BA18591菌株的培养液中分离出一种新的抗肿瘤物质，命名为BE - 18591。活性成分通过甲醇从菌丝体中提取，并经硅胶柱色谱法纯化。BE - 18591能抑制MKN - 45人胃癌细胞系以及P388细胞系的生长。在体内实验中，BE - 18591能抑制艾氏腹水瘤的生长。BE - 18591对革兰氏阳性菌和部分革兰氏阴性菌具有抗菌活性。
