通过光学显微镜、电子显微镜和X射线能谱分析证实的米诺环素相关皮肤色素沉着。

Minocycline-related cutaneous hyperpigmentation as demonstrated by light microscopy, electron microscopy and X-ray energy spectroscopy.

作者信息

Argenyi Z B, Finelli L, Bergfeld W F, Tuthill R J, McMahon J T, Ratz J L, Petroff N

出版信息

J Cutan Pathol. 1987 Jun;14(3):176-80. doi: 10.1111/j.1600-0560.1987.tb00493.x.

DOI:10.1111/j.1600-0560.1987.tb00493.x

Abstract

A 70-year-old patient with a chronic cutaneous ulcer treated by minocycline hydrochloride developed hyperpigmentation of the forearms. Biopsy material was studied by light microscopy, electron microscopy and X-ray energy spectroscopy. Granular gold-brown pigment was found in dermal histiocytes and eccrine myoepithelial cells, which gave positive reaction with Prussian blue and Fontana-Masson stains. Electron microscopy revealed intracytoplasmic granules of dark, homogeneous material and small fine particles. X-ray energy spectroscopy showed iron and other elements in smaller amounts. The different types of minocycline-related hyperpigmentation and the possible pathomechanism are discussed with special regard to the importance of the diagnostic methods.

摘要

一名接受盐酸米诺环素治疗的慢性皮肤溃疡70岁患者出现了前臂色素沉着。通过光学显微镜、电子显微镜和X射线能谱对活检材料进行了研究。在真皮组织细胞和小汗腺肌上皮细胞中发现了颗粒状金棕色色素，其对普鲁士蓝和Fontana-Masson染色呈阳性反应。电子显微镜显示胞浆内有深色、均质物质颗粒和细小颗粒。X射线能谱显示有铁和其他少量元素。结合诊断方法的重要性，讨论了不同类型的米诺环素相关色素沉着及其可能的发病机制。