Ridgway H A, Sonnex T S, Kennedy C T, Millard P R, Henderson W J, Gold S C
Br J Dermatol. 1982 Jul;107(1):95-102. doi: 10.1111/j.1365-2133.1982.tb00296.x.
Two patient receiving minocycline developed blue-black pigmentation on the legs. Biopsies from the pigmented areas demonstrated granules containing iron, a pigment with staining properties similar to melanin, and a third pigment which may be a degradation product of minocycline. Electron microscopy showed that some, but not all the granules were membrane-bound and they were situated mainly within macrophages. Analytical electron microscopy showed that the granules contained iron, sulphur, chlorine and, in one case, calcium.
两名接受米诺环素治疗的患者腿部出现蓝黑色色素沉着。对色素沉着区域进行活检，结果显示颗粒中含有铁，一种染色特性与黑色素相似的色素，以及第三种可能是米诺环素降解产物的色素。电子显微镜检查显示，部分颗粒（但并非全部）有膜包裹，且主要位于巨噬细胞内。分析电子显微镜检查显示，这些颗粒含有铁、硫、氯，在其中一个病例中还含有钙。
