Sato S, Murphy G F, Bernhard J D, Mihm M C, Fitzpatrick T B
J Invest Dermatol. 1981 Sep;77(3):264-71. doi: 10.1111/1523-1747.ep12482449.
In order to elucidate the nature and distribution of the pigment responsible for the circumscribed blue-black cutaneous hyperpigmentation occurring after administration of minocycline hydrochloride, transmission electron microscopy and energy-dispersive electron x-ray microanalysis were performed on lesional skin. Ultrastructural observations demonstrated electron-dense iron-containing particles either incorporated into a variety of siderosomes, within dermal histiocytes, free within the cytoplasm, or, rarely, scattered among dermal collagen fibers. Electron x-ray microanalysis confirmed iron content present within these particles. Although siderosomal inclusions contained occasional melanosome complexes, the degree of deposition of electron-dense iron-containing particles in dermal histiocytes seemed to be primarily responsible for the blue-black discoloration of the skin. The present study is an investigation of the structure and composition of the pigment responsible for minocycline-related cutaneous hyperpigmentation.
为了阐明盐酸米诺环素给药后出现的局限性蓝黑色皮肤色素沉着所涉及色素的性质和分布情况，我们对病变皮肤进行了透射电子显微镜检查和能量色散电子X射线微分析。超微结构观察显示，电子致密的含铁颗粒存在于真皮组织细胞内的各种含铁小体中、游离于细胞质内，或很少见地散布于真皮胶原纤维之间。电子X射线微分析证实了这些颗粒中存在铁成分。尽管含铁小体包含偶尔的黑素体复合物，但真皮组织细胞中电子致密的含铁颗粒沉积程度似乎是皮肤蓝黑色变色的主要原因。本研究是对与米诺环素相关的皮肤色素沉着所涉及色素的结构和组成的一项调查。
