Atlay R D, Weekes A R, Entwistle G D, Parkinson D J
Br Med J. 1978 Sep 30;2(6142):919-20. doi: 10.1136/bmj.2.6142.919.
A randomised crossover trial was performed in 55 pregnant women who complained of heartburn to see whether alkali or acid treatment alleviated it. Each woman was given a week's treatment with an acid mixture, an alkali mixture, and a placebo in randomised order. Both acid and alkali mixtures were better than placebo, but there was no significant difference between the acid and alkali treatments. Together with the inconsistent reports of some patients, these findings suggest that both acid reflux and bile regurgitation may cause heartburn in pregnant women and that other factors may also play a part. Because the cause of heartburn may be difficult to determine, treatment should be empirical. If the patient does not respond to seven days' acid treatment an alkali mixture should be prescribed; there is a 98% chance that one of these treatments will relieve symptoms.
对55名主诉有胃灼热的孕妇进行了一项随机交叉试验，以观察碱性或酸性治疗是否能缓解胃灼热。每位女性按随机顺序接受一周的酸性混合物、碱性混合物和安慰剂治疗。酸性和碱性混合物都比安慰剂效果好，但酸性和碱性治疗之间没有显著差异。结合一些患者的不一致报告，这些发现表明，胃酸反流和胆汁反流都可能导致孕妇胃灼热，其他因素也可能起作用。由于胃灼热的病因可能难以确定，治疗应基于经验。如果患者对七天的酸性治疗无反应，应开碱性混合物；这些治疗方法之一有98%的几率缓解症状。
