Department of Integrative Bioscience and Biotechnology, Institute of Anticancer Medicine Development, Sejong University, Seoul, South Korea.
Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, United States.
Front Immunol. 2022 Sep 2;13:979370. doi: 10.3389/fimmu.2022.979370. eCollection 2022.
Natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens rather than peptides. Due to their immunoregulatory properties, extensive work has been done to elucidate the immune functions of NKT cells in various immune contexts such as autoimmunity for more than two decades. In addition, as research on barrier immunity such as the mucosa-associated lymphoid tissue has flourished in recent years, the role of NKT cells to immunity in the skin has attracted substantial attention. Here, we review the contributions of NKT cells to regulating skin inflammation and discuss the factors that can modulate the functions of NKT cells in inflammatory skin diseases such as atopic dermatitis. This mini-review article will mainly focus on CD1d-dependent NKT cells and their therapeutic potential in skin-related immune diseases.
自然杀伤 T（NKT）细胞是先天样 T 淋巴细胞，它们识别糖脂抗原而不是肽。由于其免疫调节特性，二十多年来，人们进行了广泛的工作来阐明 NKT 细胞在各种免疫环境（如自身免疫）中的免疫功能。此外，近年来，随着黏膜相关淋巴组织等屏障免疫的研究蓬勃发展，NKT 细胞在皮肤免疫中的作用引起了人们的极大关注。在这里，我们综述了 NKT 细胞在调节皮肤炎症中的作用，并讨论了调节特应性皮炎等炎症性皮肤病中 NKT 细胞功能的因素。这篇综述文章将主要集中在 CD1d 依赖性 NKT 细胞及其在皮肤相关免疫疾病中的治疗潜力上。
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