Dong Jing, Jia Ya-Ding, Wu Qiang, Zhang Suhua, Jia Yali, Huang David, Wang Xiaogang
The First Hospital of Shanxi Medical University, Taiyuan, China.
Shanxi Eye Hospital, Taiyuan, Shanxi Province, China.
Br J Ophthalmol. 2017 Nov;101(11):1542-1549. doi: 10.1136/bjophthalmol-2016-309441. Epub 2017 Mar 23.
The aim of the study was to investigate the interchangeability and reliability of macular perfusion measurements using optical coherence tomography angiography.
A prospective cross-sectional observational study. Healthy adult Chinese subjects were recruited. Macular perfusion parameters were automatically analysed by software included in a spectral-domain optical coherence tomography system. The vessel density (VD) of the whole, parafovea, superior-hemi, inferior-hemi, fovea, temporal, superior, nasal and inferior quadrants as well as the foveal avascular zone (FAZ) and choroidal capillary VD (CCVD) were quantified.
A total of 51 eyes in 27 subjects were included (8 men and 19 women, mean age 24±4 years Significant differences in VD of all quadrants (all p<0.001) was detected between the 3×3 mm and 6×6 mm macular scan size. The biggest difference of VD between the two scan size was 5.14±4.03, which was not clinically meaningful. No statistically significant differences were found in FAZ or CCVD between the two different scan sizes. The mean intraclass correlation coefficient (ICC) between two measurements from the inter-rater of 20 eyes was from 0.560 to 0.893 for VD and 0.845 for FAZ. The mean ICC between two measurements from the intrarater of 20 eyes was from 0.497 to 0.870 for VD and 0.780 for FAZ.
FAZ and CCVD are interchangeable between the 3×3 mm and 6×6 mm macular scan sizes. The VD differences between the two different scan sizes are not clinically meaningful. The macular perfusion parameters presented good but not perfect reliability, which should be acknowledged in clinical practice.
本研究旨在探讨使用光学相干断层扫描血管造影术测量黄斑灌注的互换性和可靠性。
一项前瞻性横断面观察性研究。招募健康成年中国受试者。黄斑灌注参数由光谱域光学相干断层扫描系统中包含的软件自动分析。对整个黄斑、黄斑旁、上半区、下半区、中央凹、颞侧、上方、鼻侧和下方象限的血管密度（VD）以及中央凹无血管区（FAZ）和脉络膜毛细血管VD（CCVD）进行量化。
共纳入27名受试者的51只眼（8名男性和19名女性，平均年龄24±4岁）。在3×3mm和6×6mm黄斑扫描尺寸之间，所有象限的VD均存在显著差异（所有p<0.001）。两种扫描尺寸之间VD的最大差异为5.14±4.03，无临床意义。两种不同扫描尺寸之间的FAZ或CCVD未发现统计学显著差异。20只眼的评分者间两次测量的VD平均组内相关系数（ICC）为0.560至0.893，FAZ为0.845。20只眼的评分者内两次测量的VD平均ICC为0.497至0.870，FAZ为0.780。
在3×3mm和6×6mm黄斑扫描尺寸之间，FAZ和CCVD具有互换性。两种不同扫描尺寸之间的VD差异无临床意义。黄斑灌注参数具有良好但并非完美的可靠性，临床实践中应予以认可。
