Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China.
Department of Bioengineering, Stanford University, CA, USA.
Brain Stimul. 2022 Sep-Oct;15(5):1308-1317. doi: 10.1016/j.brs.2022.09.002. Epub 2022 Sep 18.
Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for noninvasive and selective control of neural activity. It is a promising tool for studying neural circuits. However, due to its infancy, basic studies and developments are still underway, including gauging key in vivo performance metrics such as spatiotemporal resolution, selectivity, specificity, and safety. In this paper, we summarize recent findings on sonogenetics to highlight technical hurdles that have been cleared, challenges that remain, and future directions for optimization.
声遗传学是指使用基因编码的、对超声有响应的介质来进行非侵入性和选择性的神经活动控制。它是研究神经回路的一种很有前途的工具。然而，由于其处于起步阶段，基础研究和发展仍在进行中，包括测量关键的体内性能指标，如时空分辨率、选择性、特异性和安全性。在本文中，我们总结了声遗传学的最新发现，以突出已经克服的技术障碍、仍然存在的挑战以及未来的优化方向。
