Wang Lei, Lai Congting, Li Dong, Luo Zisheng, Liu Lingling, Jiang Yunbin, Li Li
Key Laboratory of Agro-Products Postharvest Handling, Ministry of Agriculture and Rural Affairs, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.
Ningbo Research Institute, Zhejiang University, Ningbo 315100, China.
Antioxidants (Basel). 2022 Aug 26;11(9):1666. doi: 10.3390/antiox11091666.
Poor water solubility and low chemical stability, seriously limit the efficient bioavailability of resveratrol. Here, we propose encapsulating resveratrol in lecithin-polysaccharide self-assembled microspheres (LPSM). An LPSM was designed with a lecithin core, and alginate-carboxymethyl chitosan biolayer shell. The LPSM had a spherical shape with 12.171 ± 0.960 μm of particle size and -30.86 ± 1.37 mV of zeta potential. The introduce of lecithin remarkably increased the encapsulation efficiency of resveratrol to 92.78 ± 0.82%. The LPSM elevated the antioxidant capacity and ultraviolet resistance of resveratrol. Moreover, LPSM inhibited release in a simulated gastric environment, promoted sustained release in simulated intestinal environment, and elevated the bioavailability of resveratrol during in vitro simulated digestion. Results indicate that LPSM is promising as a carrier for resveratrol delivery to enhance stability and bioaccessibility.
白藜芦醇的低水溶性和低化学稳定性严重限制了其有效的生物利用度。在此，我们提出将白藜芦醇包裹于卵磷脂-多糖自组装微球（LPSM）中。设计了一种以卵磷脂为核心、海藻酸钠-羧甲基壳聚糖生物层为外壳的LPSM。LPSM呈球形，粒径为12.171±0.960μm，ζ电位为-30.86±1.37mV。卵磷脂的引入显著提高了白藜芦醇的包封率，达到92.78±0.82%。LPSM提高了白藜芦醇的抗氧化能力和抗紫外线性。此外，LPSM在模拟胃环境中抑制释放，在模拟肠环境中促进缓释，并在体外模拟消化过程中提高了白藜芦醇的生物利用度。结果表明，LPSM有望作为白藜芦醇递送的载体，以提高其稳定性和生物可及性。
