Guangdong Provincial Key Laboratory for Plant Epigenetics, Longhua Bioindustry and Innovation Research Institute, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
Int J Mol Sci. 2022 Sep 16;23(18):10803. doi: 10.3390/ijms231810803.
MicroRNAs (miRNAs) play crucial roles in plant development and stress responses, and a growing number of studies suggest that miRNAs are promising targets for crop improvement because they participate in the regulation of diverse, important agronomic traits. MicroRNA398 (miR398) is a conserved miRNA in plants and has been shown to control multiple stress responses and plant growth in a variety of species. There are many studies on the stress response and developmental regulation of miR398. To systematically understand its function, it is necessary to summarize the evolution and functional roles of miR398 and its target genes. In this review, we analyze the evolution of miR398 in plants and outline its involvement in abiotic and biotic stress responses, in growth and development and in model and non-model plants. We summarize recent functional analyses, highlighting the role of miR398 as a master regulator that coordinates growth and diverse responses to environmental factors. We also discuss the potential for fine-tuning miR398 to achieve the goal of simultaneously improving plant growth and stress tolerance.
MicroRNAs (miRNAs) 在植物发育和应激反应中发挥着关键作用，越来越多的研究表明，miRNAs 是作物改良的有前途的靶点，因为它们参与调节多种重要的农艺性状。MicroRNA398 (miR398) 是植物中一种保守的 miRNA，已被证明可以控制多种应激反应和植物生长在多种物种中。有许多关于 miR398 的应激反应和发育调控的研究。为了系统地了解其功能，有必要总结 miR398 及其靶基因的进化和功能作用。在这篇综述中，我们分析了植物中 miR398 的进化，并概述了它在非生物和生物胁迫反应、生长和发育以及模式和非模式植物中的参与。我们总结了最近的功能分析，强调了 miR398 作为一个主调节器的作用，它协调生长和对环境因素的多种反应。我们还讨论了微调 miR398 以实现同时提高植物生长和应激耐受性的目标的潜力。
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