Oyelami Favour Oluwapelumi, Usman Tahir, Suravajhala Prashanth, Ali Nawab, Do Duy N
The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.
College of Veterinary Sciences & Animal Husbandry, Abdul Wali Khan University, Mardan 23200, KP, Pakistan.
Pathogens. 2022 Sep 3;11(9):1009. doi: 10.3390/pathogens11091009.
Non-coding RNAs (ncRNAs) are an abundant class of RNA with varying nucleotide lengths. They have been shown to have great potential in eutherians/human disease diagnosis and treatments and are now gaining more importance for the improvement of diseases in livestock. To date, thousands of ncRNAs have been discovered in the bovine genome and the continuous advancement in deep sequencing technologies and various bioinformatics tools has enabled the elucidation of their roles in bovine health. Among farm animals' diseases, mastitis, a common inflammatory disease in cattle, has caused devastating economic losses to dairy farmers over the last few decades. Here, we summarize the biology of bovine mastitis and comprehensively discuss the roles of ncRNAs in different types of mastitis infection. Based on our findings and relevant literature, we highlighted various evidence of ncRNA roles in mastitis. Different approaches (in vivo versus in vitro) for exploring ncRNA roles in mastitis are emphasized. More particularly, the potential applications of emerging genome editing technologies, as well as integrated omics platforms for ncRNA studies and implications for mastitis are presented.
非编码RNA（ncRNAs）是一类丰富的RNA，其核苷酸长度各不相同。它们已被证明在真兽类/人类疾病诊断和治疗中具有巨大潜力，目前对于改善家畜疾病也变得越来越重要。迄今为止，在牛基因组中已发现数千种ncRNAs，深度测序技术和各种生物信息学工具的不断进步使得阐明它们在牛健康中的作用成为可能。在农场动物疾病中，乳腺炎是牛常见的炎症性疾病，在过去几十年给奶农造成了巨大的经济损失。在这里，我们总结了牛乳腺炎的生物学特性，并全面讨论了ncRNAs在不同类型乳腺炎感染中的作用。基于我们的研究结果和相关文献，我们强调了ncRNAs在乳腺炎中作用的各种证据。强调了探索ncRNAs在乳腺炎中作用的不同方法（体内与体外）。更特别的是，介绍了新兴基因组编辑技术的潜在应用，以及用于ncRNA研究的综合组学平台及其对乳腺炎的影响。
